Green light to a green arylation
Green light to a green arylation
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DOI：
10.1016/j.trechm.2022.06.008
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发表时间：
2022-07
影响因子：
15.7
通讯作者：
M. Hossain;T. Gianetti
中科院分区：
文献类型：
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作者：
M. Hossain;T. Gianetti
有机光催化剂对C（sp2）-X键的光活化，揭示了加速无偏羰基α位温和芳基化反应的前景。基于过渡金属的方法是普遍存在的，而无金属的方法是稀缺的，并且严重依赖于活性羰基和/或电子偏置芳基卤化物。我们的团队开发了富电子吖啶鎓，以低能量绿光介导的光氧化还原方案，从未官能化的底物开始催化酮的直接α-芳基化，从而产生无数的生物活性剂和药物制剂。
Photoactivation of C (sp2)-X bond by an organic photocatalyst unveils the prospect of accelerated mild arylation at the α position of unbiased carbonyls. Transition-metal based approaches are ubiquitous while metal-free methods are scarce and heavily depend on activated carbonyls and/or electronically biased aryl halides. Our group developed electron rich acridiniums to catalyze direct α-arylation of ketones starting with unfunctionalized substrates in a low energy green-lightmediated photoredox protocol leading to myriad of bioactive and pharmaceutical agents.