Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information
Ventral Hippocampal CA1 Pyramidal Neurons Encode Nociceptive Information
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DOI：
10.1007/s12264-023-01086-x
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发表时间：
2023-07
影响因子：
5.6
通讯作者：
Yue Wang;Naizheng Liu;Longyu Ma;Lupeng Yue;Shuang Cui;Fengyu Liu;Ming Yi;You Wan
中科院分区：
文献类型：
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作者：
Yue Wang;Naizheng Liu;Longyu Ma;Lupeng Yue;Shuang Cui;Fengyu Liu;Ming Yi;You Wan
海马作为边缘系统的主要结构，在疼痛的感知和慢性化过程中起着关键作用。腹侧海马CA 1（vCA 1）与焦虑、压力和恐惧等负面情绪密切相关，但vCA 1神经元如何编码伤害性信息仍不清楚。使用在体电生理记录，我们的特点vCA 1锥体神经元亚群表现出抑制性或兴奋性反应足底刺激，并涉及在幼稚大鼠的编码刺激方式。vCA 1锥体神经元的功能异质性进一步确定在神经病理性疼痛条件下：抑制性反应神经元的比例和幅度的机械异常性疼痛，并有助于混淆编码的无害和有害的刺激，而兴奋性反应神经元仍然有助于刺激特性的歧视。vCA 1中增加的θ功率和θ-棘波耦合与伤害性行为相关。vCA 1锥体神经元的光遗传抑制诱导机械异常性疼痛的幼稚大鼠，而整体抑制vCA 1活性的化学发生逆转具有镇痛作用的神经病理性疼痛的大鼠。这些结果为vCA 1表达伤害性信息提供了直接证据。
As a main structure of the limbic system, the hippocampus plays a critical role in pain perception and chronicity. The ventral hippocampal CA1 (vCA1) is closely associated with negative emotions such as anxiety, stress, and fear, yet how vCA1 neurons encode nociceptive information remains unclear. Usingin vivoelectrophysiological recording, we characterized vCA1 pyramidal neuron subpopulations that exhibited inhibitory or excitatory responses to plantar stimuli and were implicated in encoding stimuli modalities in naïve rats. Functional heterogeneity of the vCA1 pyramidal neurons was further identified in neuropathic pain conditions: the proportion and magnitude of the inhibitory response neurons paralleled mechanical allodynia and contributed to the confounded encoding of innocuous and noxious stimuli, whereas the excitatory response neurons were still instrumental in the discrimination of stimulus properties. Increased theta power and theta-spike coupling in vCA1 correlated with nociceptive behaviors. Optogenetic inhibition of vCA1 pyramidal neurons induced mechanical allodynia in naïve rats, whereas chemogenetic reversal of the overall suppressed vCA1 activity had analgesic effects in rats with neuropathic pain. These results provide direct evidence for the representations of nociceptive information in vCA1.