Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus
Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus
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DOI：
10.1086/520589
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发表时间：
2007-11-15
影响因子：
6.4
通讯作者：
Geisbert, Thomas W.
中科院分区：
文献类型：
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作者：
Larsen, Thomas;Stevens, Edward L.;Geisbert, Thomas W.
猕猴感染扎伊尔埃博拉病毒会导致致命疾病，其发病机制与人类相似。在几项独立治疗研究中，我们注意到 6 只恒河猴的组织向性发生了改变，它们比具有典型病程的恒河猴存活时间更长。这 6 只猕猴的平均死亡时间为 21.7 天，明显长于 20 只未经治疗的历史对照动物的平均死亡时间 8.3 天。除了寿命显着延长之外，这 6 只动物还表现出各种恶化的临床症状，以及未经治疗的对照动物中未见的病理结果，以及脑、眼、胰腺、甲状腺和肺中存在病毒抗原。我们建议治疗延长了疾病的病程，并允许病毒感染在典型模型中通常不受影响的组织。
Zaire Ebola virus infection in macaques causes a fatal disease with a pathogenesis similar to that in humans. During several independent therapy studies, we noted altered tissue tropism in 6 rhesus macaques that survived longer than those with a typical disease course. The mean time to death for these 6 macaques was 21.7 days, which is significantly longer than the average mean time to death of 8.3 days for 20 untreated historical control animals. In addition to living significantly longer, these 6 animals exhibited a variety of deteriorating clinical signs with pathologic findings that were not seen in the untreated control animals, as well as the presence of viral antigen in the brain, eye, pancreas, thyroid, and lung. We suggest that treatment extended the time course of the disease and permitted the virus to infect tissues not usually affected in the typical model.