A teleost polymeric Ig receptor exhibiting two Ig-like domains transports tetrameric IgM into the skin
A teleost polymeric Ig receptor exhibiting two Ig-like domains transports tetrameric IgM into the skin
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DOI：
10.4049/jimmunol.178.9.5682
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发表时间：
2007-05-01
影响因子：
4.4
通讯作者：
Suzuki, Yuzuru
中科院分区：
文献类型：
--
作者：
Hamuro, Koji;Suetake, Hiroaki;Suzuki, Yuzuru
皮肤粘液IgM是硬骨鱼皮肤粘膜免疫系统中的重要分子。然而，与该分子相关的转运机制尚不清楚。在这项研究中，我们从硬骨鱼Takifugu rubripe(河豚)中分离到一个编码多聚体Ig受体(PIgR)的基因。已知该基因是哺乳动物肠道中的Ig转运蛋白。我们的研究进一步证明，河豚的pIgR在皮肤中表达，并且在皮肤粘液中有一段pIgR与四聚体IgM结合。这些结果表明，皮肤pIgR将四聚体IgM转运到皮肤粘液中。河豚pIgR显示出一种独特的结构，只包含两个Ig样结构域，分别对应于哺乳动物pIgR的结构域I和结构域415。该结构足以与四聚体IgM成功结合。因此，硬骨鱼皮肤通过一种独特的pIgR，采用与哺乳动物肠道相同的Ig运输系统。免疫学杂志，2007,178：5682-5689。
The skin mucus IgM is an important molecule in the mucosal immune system of teleost skin. However, the transport mechanism associated with this molecule has yet to be clarified. In this study, we isolated a gene encoding a polymeric Ig receptor (pIgR) from a species of teleost fish, Takifugu rubripes (fugu). This gene is known to be an Ig transporter in the intestine of mammals. Our studies further demonstrated that fugu pIgR was expressed in the skin and that a fragment of pIgR bound to tetrameric IgM in the skin mucus. These results indicate that the skin pIgR transports tetrameric IgM into the skin mucus. The fugu pIgR exhibits a unique structure containing only two Ig-like domains corresponding to domain I and domain 415 of mammalian pIgR. This structure was sufficient for successful binding to tetrameric IgM. Teleost skin thus adopts the same Ig transport system as mammalian intestine via a unique pIgR. The Journal of Immunology, 2007, 178: 5682-5689.