Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs
Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs
复制标题
DOI：
10.7164/antibiotics.55.552
复制
发表时间：
2002-06-01
影响因子：
3.3
通讯作者：
Lee, JJ
中科院分区：
文献类型：
--
作者：
Lee, HJ;Lee, JH;Lee, JJ
在寻找新的天然抗血管生成化合物的过程中，我们发现一株未知真菌菌株B90911的培养液对体外培养的人脐静脉内皮细胞(HUVEC)的毛细血管样管形成有抑制作用。通过生测分离分离得到4个活性化合物，经波谱分析鉴定其结构分别为索罗欣(1)、甲基星酸(2)和2个新的星酸衍生物3-氯星酸(3)和3，5-二氯星酸(4)。这些化合物显著抑制了血管内皮生长因子诱导的血管内皮细胞的管状形成，提示星形类化合物可作为抗血管生成的药物进行进一步的研究。
In the search for new naturally occurring anti-angiogenic compounds, we found that a culture broth of an unidentified fungal strain B90911 exerted inhibitory activity on capillary-like tube formation of human umbilical vein endothelial cells (HUVEC) in vitro. Four active compounds were isolated by bioassay-guided separation and their structures were identified to be sulochrin (1), methyl asterric acid (2), and two new asterric acid derivatives, 3-chloroasterric acid (3), and 3,5-dichloroasterric acid (4) by spectroscopic analyses. These compounds significantly inhibited the VEGF-induced tube formation of HUVEC, suggesting that asterric derivatives could be useful for further study as anti-angiogenic agents.