Acoustic Emissions From Loaded and Unloaded Knees to Assess Joint Health in Patients With Juvenile Idiopathic Arthritis
Acoustic Emissions From Loaded and Unloaded Knees to Assess Joint Health in Patients With Juvenile Idiopathic Arthritis
复制标题
通过加载和卸载膝盖的声发射来评估幼年特发性关节炎患者的关节健康状况
DOI：
10.1109/jbhi.2021.3081429
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发表时间：
2021
影响因子：
7.7
通讯作者：
Inan, Omer T.
中科院分区：
文献类型：
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作者：
Gharehbaghi, Sevda;Whittingslow, Daniel C.;Ponder, Lori A.;Prahalad, Sampath;Inan, Omer T.
我们研究并比较了关节声发射（JAE）在加载和卸载膝盖作为数字生物标志物，用于评估膝关节健康状况的治疗过程中的青少年特发性关节炎（JIA）的患者。MethodsJAE记录从38名参与者，进行10次重复的卸载屈曲/伸展（FE）和加载蹲下练习。提出了一种新的检测和排除摩擦噪声和松散麦克风伪影的算法，并提取了72个特征。这些特征基于不同的标准被向下选择以训练三个逻辑回归分类器。分类器使用健康和治疗前数据进行训练，并用于预测具有随访记录的相同JIA患者的治疗后数据的膝关节健康评分。此膝关节健康评分代表的概率有JIA在一个主题（0为健康和1关节炎）。ResultsPost-treatment膝关节健康评分低于治疗前的分数，同意与成功治疗的临床记录。关于加载与卸载膝关节评分，深蹲达到了更高的分数平均相比FEs.ConclusionIn健康受试者与光滑的软骨，膝关节评分的深蹲和FEs是相似的，表明振动的关节面的摩擦不显着改变的联合负荷。然而，在JIA受试者中，深蹲的评分高于FE的评分，这表明这两种练习包含不同的、可能与临床相关的信息，可用于进一步改善JIA中这种新的评估方式。
ObjectiveWe studied and compared joint acoustical emissions (JAEs) in loaded and unloaded knees as digital biomarkers for evaluating knee health status during the course of treatment in patients with juvenile idiopathic arthritis (JIA).MethodsJAEs were recorded from 38 participants, performing 10 repetitions of unloaded flexion/extension (FE) and loaded squat exercises. A novel algorithm was developed to detect and exclude rubbing noise and loose microphone artifacts from the signals, and then 72 features were extracted. These features were down-selected based on different criteria to train three logistic regression classifiers. The classifiers were trained with healthy and pre-treatment data and were used to predict the knee health scores of post-treatment data for the same patients with JIA who had a follow-up recording. This knee health score represents the probability of having JIA in a subject (0 for healthy and 1 for arthritis).ResultsPost-treatment knee health scores were lower than pre-treatment scores, agreeing with the clinical records of successful treatment. Regarding loaded versus unloaded knee scores, the squats achieved a higher score on average compared to FEs.ConclusionIn healthy subjects with smooth cartilage, the knee scores of squats and FEs were similar indicating that vibrations from the friction of articulating surfaces do not significantly change by the joint load. However, in subjects with JIA, the scores of squats were higher than the scores of FEs, revealing that these two exercises contain different, possibly clinically relevant, information that could be used to further improve this novel assessment modality in JIA.