Tissue hypertrophy and epithelial proliferation rate in the gut of rats fed on bread and haricot beans (Phaseolus vulgaris)
Tissue hypertrophy and epithelial proliferation rate in the gut of rats fed on bread and haricot beans (Phaseolus vulgaris)
复制标题
喂食面包和扁豆（菜豆）的大鼠肠道组织肥大和上皮增殖率
DOI：
10.1079/bjn19960031
复制
发表时间：
1996
影响因子：
3.6
通讯作者：
J. Mathers
中科院分区：
文献类型：
--
作者：
F. B. Key;D. McClean;J. Mathers
本研究旨在验证大肠中短链脂肪酸（SCFA）产量增加会增加肠上皮细胞增殖率（EPR）的假设。进行了两个实验，其中大鼠喂食面包（全麦或白色）为基础的饮食含有分级量的煮熟的扁豆（菜豆）豆;后者是丰富的可发酵碳水化合物的来源。豆类的消费与SCFA产量的几倍增加有关，其中丁酸盐的相对增加最大。尽管SCFA的产生有很大的增加，但没有证据表明这对十二指肠中的EPR有任何影响。在基础饮食中含有全麦面包（实验1），在盲肠或结肠中增加SCFA供应对EPR没有影响，但在以白色面包为基础的饮食（实验2）中添加豆类，在盲肠中增加SCFA供应和EPR。SCFA导致EPR高于正常水平的证据并不令人信服。在SCFA供应增强与EPR增加相关的情况下，这种增加可能是（1）从低增殖状态向正常状态，（2）伴随组织肥大的短暂现象或（3）对细胞脱落或凋亡导致的细胞损失增加的稳态反应。这不太可能与结肠癌的风险有任何直接联系
The present study was designed to test the hypothesis that increasing short-chain fatty acid (SCFA)production in the large bowel increases gut epithelial proliferation rate (EPR). Two experiments were carried out in which rats were fed on bread (wholemeal or white)-based diets containing graded amounts of cooked haricot (Phaseofus vulgaris) beans; the latter are a rich source of fermentable carbohydrates. Consumption of beans was associated with several-fold increases in SCFA production with the greatest relative increase being for butyrate. Despite the very large increase in SCFA production, there was no evidence that this had any effect on EPR in the duodenum. Where the basal diet contained wholemeal bread (Expt 1) there was no effect of enhanced SCFA supply on EPR in either the caecum or colon, but with the white bread-based diet (Expt 2) adding beans produced increments in both SCFA supply and EPR in the caecum. Evidence that SCFA are responsible for enhanced EPR above normal levels is not convincing. In those instances where enhanced SCFA supply is associated with increased EPR, the increase may be (1) from a hypoproliferative state towards normal, (2) a transient phenomenon accompanying tissue hypertrophy or (3) a homeostatic response to increased cell loss by cell sloughing or apoptosis. It is not likely that there is any direct link with risk of colon cancer
影响因子：
11.2
作者：
S. Preston‐Martin;M. Pike;R. Ross;P. A. Jones;B. Henderson
通讯作者：
S. Preston‐Martin;M. Pike;R. Ross;P. A. Jones;B. Henderson
膳食纤维对小型猪肠粘膜细胞增殖的影响可能不是主要通过发酵介导的。
DOI：
10.1093/jn/122.4.906
发表时间：
1992
期刊：
The Journal of nutrition
影响因子：
--
作者：
Fleming,SE;Fitch,MD;DeVries,S
通讯作者：
DeVries,S