Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain.
Metabolic disposition and elimination studies of a radiolabelled biodegradable polymeric implant in the rat brain.
复制标题
大鼠大脑中放射性标记的可生物降解聚合物植入物的代谢处置和消除研究。
DOI：
10.1016/0142-9612(94)90166-x
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发表时间：
1994
期刊：
影响因子：
14
通讯作者：
Villemure,JG
中科院分区：
文献类型：
--
作者：
Domb,AJ;Rock,M;Schwartz,J;Perkin,C;Yipchuk,G;Broxup,B;Villemure,JG
研究了植入大鼠脑内的酸酐共聚物聚[1,3-双(对羧基苯氧基丙烷):癸二酸]20:80[P(CPP:SA)20:80]的代谢处置和消除过程。制备了两种聚合物，一种具有[ 14 C]SA和未标记的CPP，另一种具有[ 14 C]CPP和未标记的SA的共聚物。利用这两种聚合物，我们能够研究聚合物降解后每种单体的代谢分布。将载有 AJ,AJ-双(2-氯乙基)-JV-亚硝基脲或不含药物的聚合物晶片植入大鼠脑中。对于植入[14C]SA标记聚合物的大鼠，在植入后7天，约40%的放射性在呼出的CO2中发现，10%在尿液中，约2%在粪便中，约10%残留在装置中。另一方面，在此期间只有4%的[14C]CPP单体通过尿液和粪便消除。载药聚合物比空白聚合物降解得更快。这项研究支持了这样的理论，即聚合物是一种可生物降解的材料，可用于将药物直接、特异性地输送到目标器官中，并可以在一段时间内提供药物的持续释放。生物材料（1994）15，（9）681–688
The metabolic disposition and elimination process of the anhydride co-polymer poly[1,3-bis(p-carboxyphenoxypropane): sebacic acid] 20:80 [P(CPP:SA)20:80] implanted in the rat brain was studied. Two polymers were prepared, one with [14C]SA and unlabelled CPP, and the other co-polymer with [14C]CPP and unlabelled SA. With these two polymers we were able to study the metabolic disposition of each monomer after polymer degradation. Polymer wafers loaded with AJ,AJ-bis(2-chloroethyl)-JV-nitrosourea or without the drug were implanted in the rat brain. For the rats implanted with the [14C]SA-labelled polymer, approximately 40% of the radioactivity was found in the expired CO2, 10% in the urine, about 2% in the faeces and about 10% remained in the device 7d after implantation. On the other hand, only 4% of the [14C]CPP monomer was eliminated by urine and faeces during this period. The drug-loaded polymer degraded faster than the blank polymer. This study supports the theory that the polymer is a biodegradable material that can be used for the direct and specific delivery of drugs into a targeted organ and can provide continued release of drugs over a period of time. Biomaterials (1994)15, (9) 681–688