Changes in bone resorption during the menstrual cycle
Changes in bone resorption during the menstrual cycle
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DOI：
10.1359/jbmr.1999.14.4.609
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发表时间：
1999-04-01
影响因子：
6.2
通讯作者：
Arnaud, CD
中科院分区：
文献类型：
--
作者：
Chiu, KM;Ju, J;Arnaud, CD
为了确定女性性激素在月经周期中的周期性变化是否与骨形成和骨吸收的变化有关，我们对20名健康绝经前妇女在一个月经周期中每周三次测定血清骨特异性碱性磷酸酶(BAP)、骨钙素(OC)和骨吸收标志物--血清和尿脱氧吡啶(DPYR)。血清雌二醇(E-2)和孕酮(P)呈周期性波动。血清DPYR在卵泡期(FP)高于黄体期(P=0.027)，血清BAP、OC和尿DPYR水平在整个周期中没有显著变化。血清DPYR与6天(p=0.011)和8天(p=0.001)的血清E-2呈负相关，与同时测定的P(p=0.033)、2天(p=0.002)、4天(p=0.003)和6天(p=0.014)呈负相关。BaP与6天前测得的E-2呈负相关(p=0.006)。女性月经周期内血清E-2、P水平与OC、尿DPYR无显著相关性，BAP与月经周期并发DPYR呈正相关(P=0.015)，与年龄呈负相关(r(S)=-0.48，P=0.036)。尿DPYR水平越高的女性，血清OC水平越高(r(S)=0.49，P=0.033)，髋部骨密度有降低的趋势(r(S)=-0.4，P=0.078)。我们的结论是，在正常月经周期的FP期间观察到的低E-2和/或P水平与骨吸收增加有关。这些关系表明，从月经初潮到绝经，正常女性每月都会经历骨吸收增加的情况。
To determine if the cyclic changes of female sex hormones during the menstrual cycle are related to changes in bone formation and resorption, we measured serum bone-specific alkaline phosphatase (BAP) and osteocalcin (OC) and bone resorption markers, serum and urine deoxypyridinoline (Dpyr), three times per week during one menstrual cycle in 20 healthy premenopausal women. Serum estradiol (E-2) and progesterone (P) showed characteristic cyclic fluctuations. Serum Dpyr was higher during the follicular phase (FP) than in the luteal phase (p = 0.027), Serum BAP, OC, and urine Dpyr levels did not change substantially across the cycle. Serum Dpyr correlated negatively with serum E-2 values measured 6 (p = 0.011) and 8 (p = 0.001) days earlier and with P measured concurrently (p = 0.033) 2 (p = 0.002), 4 (p = 0.003), and 6 (p = 0.014) days earlier. BAP correlated negatively with E-2 measured 6 days earlier (p = 0.006). We found no statistically significant correlations of E-2 or P with OC or urine Dpyr within women over their cycles, BAP was positively correlated with concurrent serum Dpyr (p = 0.015) during the menstrual cycle, Serum OC levels correlated inversely with age (r(s) = -0.48, p = 0.036). Women with higher mean urine Dpyr levels had higher mean serum OC levels (r(s) = 0.49, p = 0.033) and showed a trend toward lower hip bone mineral density (r(s) = -0.40, p = 0.078). We conclude that the low level of E-2 and/or P observed during the FP of the normal menstrual cycle is associated with increased bone resorption. These relationships suggest that normal women experience monthly episodes of increased bone resorption from menarche to menopause.