Fear conditioning drives profilin into amygdala dendritic spines
Fear conditioning drives profilin into amygdala dendritic spines
复制标题
DOI：
10.1038/nn1672
复制
发表时间：
2006-04-01
影响因子：
25
通讯作者：
LeDoux, JE
中科院分区：
文献类型：
--
作者：
Lamprecht, R;Farb, CR;LeDoux, JE
脊柱形态学的变化可能是记忆形成的基础，但有助于这种改变的分子机制知之甚少。在这里，我们表明，大鼠的恐惧条件反射导致profilin，肌动蛋白聚合调节蛋白的运动，在杏仁核外侧树突棘，这些棘进行扩大，在他们的突触后密度（PSD）。更大比例的profilin含有扩大的PSD的棘可能有助于增强关联诱导的突触反应在外侧杏仁核恐惧学习。
Changes in spine morphology may underlie memory formation, but the molecular mechanisms that subserve such alterations are poorly understood. Here we show that fear conditioning in rats leads to the movement of profilin, an actin polymerization-regulatory protein, into dendritic spines in the lateral amygdala and that these spines undergo enlargements in their postsynaptic densities (PSDs). A greater proportion of profilin-containing spines with enlarged PSDs could contribute to the enhancement of associatively induced synaptic responses in the lateral amygdala following fear learning.