Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease - A comprehensive study
Calcium oxalate deposition in renal cell carcinoma associated with acquired cystic kidney disease - A comprehensive study
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DOI：
10.1097/01.pas.0000152131.58492.97
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发表时间：
2005-04-01
影响因子：
5.6
通讯作者：
Truong, LD
中科院分区：
文献类型：
--
作者：
Sule, N;Yakupoglu, U;Truong, LD
获得性囊性肾病（ACKD）的主要并发症是频繁发生肾脏肿瘤，包括肾细胞癌（RCC）。草酸钙（CaOx）的瘤内沉积是ACKD相关RCC的一个明显特征，但这种类型的RCC的几个特征尚不清楚。分析了13年内确定的30例终末期肾病（ESRD）相关RCC的特征，包括8例CaOx沉积。对CaOx阳性（+）和阴性（-）肾癌的病理和临床特征进行评价和比较。CaOx+ RCCs表现出更高的双侧性和多灶性倾向。七个肿瘤显示出独特的形态学特征，肿瘤细胞具有不明确的细胞膜，丰富的颗粒状嗜酸性细胞质，大的核，和突出的核仁。1例为透明细胞型。无论组织学类型，所有肿瘤显示近端肾小管分化。CaOx+和CaOx-RCC之间的肿瘤分期、增殖和凋亡率无显著差异。CaOx+ RCC占所有ESRD相关RCC的很大一部分。这些RCC中的大多数显示出独特的形态学特征。近端肾小管细胞分化与ESRD介导的高血清水平可能对瘤内CaOx沉积具有重要的病理意义。这些RCC似乎有一个相对良好的预后。
The main complication of acquired cystic kidney disease (ACKD) is frequent development of renal tumors, including renal cell carcinoma (RCC). Intratumoral deposition of calcium oxalate (CaOx) is a distinct feature of ACKD-associated RCCs, but several features of this type of RCC are not known. Features of the 30 end-stage renal disease (ESRD)-associated RCCs identified within a 13-year period, including eight with CaOx deposition, were analyzed. Pathologic and clinical features of CaOx positive (+) and negative (-) RCCs were evaluated and compared. The CaOx+ RCCs showed higher tendency for bilaterality and multifocality. Seven tumors displayed distinctive morphologic features characterized by tumor cells with ill-defined cell membrane, abundant granular eosinophilic cytoplasm, large nuclei, and prominent nucleoli. One tumor was of clear cell type. Regardless of histologic type, all tumors displayed a proximal tubular differentiation. No significant difference was noted for tumors' stage, proliferation, and apoptosis rate between the CaOx+ and CaOx-RCCs. CaOx+ RCCs account for a significant portion of all ESRD-associated RCCs. The majority of these RCCs display a distinctive morphologic profile. Proximal tubular cell differentiation in conjunction with ESRD-mediated high serum level may be pathogenetically important for intratumoral CaOx deposition. These RCCs seems to have a relatively good prognosis.