INFLUENCE OF BETA-ADRENERGIC-BLOCKADE ON GLUCOSE-INDUCED THERMOGENESIS IN MAN
INFLUENCE OF BETA-ADRENERGIC-BLOCKADE ON GLUCOSE-INDUCED THERMOGENESIS IN MAN
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DOI：
10.1172/jci111070
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发表时间：
1983-01-01
影响因子：
15.9
通讯作者：
WAHREN, J
中科院分区：
文献类型：
--
作者：
ACHESON, K;JEQUIER, E;WAHREN, J
β的作用-在健康男性受试者中检查了肾上腺素介导的交感神经活动在调节葡萄糖诱导的产热作用中的作用。使用通气罩技术，在高胰岛素血症和高血糖症的条件下（葡萄糖钳夹技术，胰岛素输注1 mU/kg/min，葡萄糖水平高于基础值125 mg/dl），在β-葡萄糖注射之前和之后连续测量呼吸气体交换。肾上腺素能阻滞（静脉注射普萘洛尔，3 mg推注加0.1 mg/min持续2 h）。 在系列1中输注胰岛素和葡萄糖2小时后，葡萄糖摄取增加至23.5 ± 0.0001。2.3 mg/kg/min，胰岛素浓度达到199 ± 0.001。21 μ U/ml。与此同时，能量消耗增加了0.39 ±。0.05 kcal/min高于基础值。葡萄糖诱导的产热作用（GIT）为6.5 ± 0.5。术前0.3%，术后4.6 ±。普萘洛尔组为0.5%（P < 0.02）。在系列2中，胰岛素和葡萄糖输注持续4小时，不给予普萘洛尔。在第2和第4小时之间，葡萄糖摄取增加（+12%），胰岛素水平增加（+40%），但能量消耗和GIT保持不变。受试者在系列3接受盐水输注单独为3小时，在这个时候普萘洛尔管理中的系列1中添加在另外的2小时期间。在生理盐水或普萘洛尔输注期间，未观察到能量消耗的变化。这些数据证明存在β-肾上腺素能介导的交感神经成分在健康人受试者葡萄糖诱导产热中的作用。这一因素在调节人体正常体重方面可能具有重要意义。
The role of .beta.-adrenergically mediated sympathetic nervous activity in the regulation of glucose-induced thermogenesis was examined in healthy male subjects. Respiratory gas exchange was measured continuously, using the ventilated hood technique, under conditions of hyperinsulinemia and hyperglycemia (glucose clamp technique, insulin infusion 1 mU/kg per min, glucose levels 125 mg/dl above basal) before and after .beta.-adrenergic blockade (i.v. propranolol, 3-mg bolus plus 0.1 mg/min for 2 h). After 2 h of insulin and glucose infusion in series 1, glucose uptake had increased to 23.5 .+-. 2.3 mg/kg per min and insulin concentration to 199 .+-. 21 .mu.U/ml. Simultaneously, the energy expenditure had risen by 0.39 .+-. 0.05 kcal/min above basal. The glucose-induced thermogenesis (GIT) was 6.5 .+-. 0.3% before and 4.6 .+-. 0.5% (P < 0.02) after propranolol. In series 2, insulin and glucose infusion was continued for 4 h without propranolol administration. Glucose uptake rose (+12%) and insulin levels increased (+40%) between the 2nd and 4th h but energy expenditure and GIT remained unchanged. Subjects in series 3 received saline infusion alone for 3 h, at which time propranolol administration as in series 1 was added during a further 2-h period. No changes in energy expenditure were seen during saline or propranolol infusion. These data demonstrate the presence of a .beta.-adrenergically mediated sympathetic nervous component in glucose-induced thermogenesis in healthy human subjects. This factor may be of importance in the regulation of normal body weight in man.