The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases.
The aryl hydrocarbon receptor: regulation of hematopoiesis and involvement in the progression of blood diseases.
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DOI：
10.1016/j.bcmd.2010.01.005
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发表时间：
2010-04-15
影响因子：
2.3
通讯作者：
Gasiewicz, Thomas A.
中科院分区：
文献类型：
--
作者：
Casado, Fanny L.;Singh, Kameshwar P.;Gasiewicz, Thomas A.
芳香烃受体（arylhydrocarbonreceptor，AhR）是一种碱性螺旋-环-螺旋蛋白，属于环境敏感PAS（Per-ARNT-Sim）蛋白超家族。已经描述了大量的配体结合AhR并促进其核转位。在细胞核中，AhR及其二聚化伴侣AhR核转位酶（ARNT），也称为HIF 1 β，形成DNA结合复合物，作为转录调节因子。动物和人类的数据表明，除了其介导的异生物质和/或未知的内源性配体的反应，AhR有一个角色，虽然尚未确定，在细胞周期和炎症的调节。AhR似乎还以细胞特异性方式在发育和成年期间调节造血和免疫系统。虽然意外暴露于异生物质AhR配体与人类白血病有关，但AhR参与的具体机制仍不完全清楚。然而，最近的数据与AhR在维持造血干细胞和/或祖细胞（HSC/HPC）中的功能作用一致。强调造血干细胞/HPC的AhR调控的研究提供了一个合理的框架，以了解他们的生物学，AhR在造血疾病中的作用，并为这些疾病制定干预措施的手段。
The aryl hydrocarbon receptor (AhR) is a basic helix-loop-helix protein that belongs to the superfamily of environment-sensing PAS (Per-ARNT-Sim) proteins. A large number of ligands have been described to bind AhR and promote its nuclear translocation. In the nucleus, the AhR and its dimerization partner the AhR nuclear translocase (ARNT), also known as HIF1β, form a DNA-binding complex that acts as a transcriptional regulator. Animal and human data suggest that, beyond its mediating responses to xenobiotic and/or unknown endogenous ligands, the AhR has a role, although as yet undefined, in the regulation of cell cycle and inflammation. The AhR also appears to regulate the hematopoietic and immune systems during development and adult life in a cell-specific manner. While accidental exposure to xenobiotic AhR ligands has been associated with leukemia in humans, the specific mechanisms of AhR involvement are still not completely understood. However, recent data are consistent with a functional role of the AhR in the maintenance of hematopoietic stem and/or progenitor cells (HSCs/HPCs). Studies highlighting AhR-regulation of HSCs/HPCs provide a rational framework to understand their biology, a role of the AhR in hematopoietic diseases, and a means to develop interventions for these diseases.
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DOI：
10.1093/toxsci/kfn149
发表时间：
2008-11
期刊：
Toxicological sciences : an official journal of the Society of Toxicology
影响因子：
--
作者：
Bunger MK;Glover E;Moran SM;Walisser JA;Lahvis GP;Hsu EL;Bradfield CA
通讯作者：
Bradfield CA
影响因子：
4.5
作者：
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通讯作者：
Winn, Louise M.
影响因子：
4.5
作者：
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通讯作者：
Hanberg, Annika
影响因子：
3.6
作者：
Allan, LL;Sherr, DH
通讯作者：
Sherr, DH
DOI：
10.1073/pnas.0701764104
发表时间：
2007-05-22
影响因子：
11.1
作者：
Fritsche, Ellen;Schaefer, Claudia;Krutmann, Jean
通讯作者：
Krutmann, Jean