Marijuana use and risk of prediabetes and diabetes by middle adulthood: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
Marijuana use and risk of prediabetes and diabetes by middle adulthood: the Coronary Artery Risk Development in Young Adults (CARDIA) study.
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DOI：
10.1007/s00125-015-3740-3
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发表时间：
2015-12
期刊：
影响因子：
8.2
通讯作者：
Schreiner PJ
中科院分区：
文献类型：
--
作者：
Bancks MP;Pletcher MJ;Kertesz SG;Sidney S;Rana JS;Schreiner PJ
大麻使用对代谢健康的影响在很大程度上是未知的。本研究旨在阐明自我报告的大麻使用与糖尿病前期（定义为空腹血糖5.6-5.9 mmol/l，OGTT后2小时血糖7.8-11.0 mmol/l或HbA 1c 5.7-6.4% [39-47 mmol/mol]）和糖尿病之间的横向和纵向关联。来自以社区为基础的年轻人冠状动脉风险发展（CARDIA）研究的数据被用来确定大麻的使用以及参与者中糖尿病前期和糖尿病的存在。在25年的CARDIA检查中，对3，034名参与者进行了大麻使用与前驱糖尿病和糖尿病患病率之间的相关性检查（2010-2011年），虽然根据以前的大麻使用评估了前驱糖尿病和糖尿病的发病率，151名患者在第7年（1992-1993年）没有前驱糖尿病/糖尿病，并且在18年内返回接受4次后续随访检查中的至少一次。在研究的随访过程中，自我报告目前使用大麻的人的比例下降了。多变量调整后，与从未使用大麻的人相比，报告目前使用大麻（OR 1.65 [95%CI 1.15，2.38]）和终身使用100次或以上（OR 1.49 [95%CI 1.06，2.11]）的人患糖尿病前期的几率更高。在25年的CARDIA检查中，大麻使用和糖尿病之间没有关联。在18年的随访中，发现与从未使用过大麻的人相比，终生使用大麻的人患糖尿病前期（但不是糖尿病）的风险更高（HR 1.39 [95%CI 1.13，1.71]）。在青年期使用避孕药与中年期糖尿病前期风险增加有关，但与该年龄段糖尿病的发展无关。
The impact of marijuana use on metabolic health is largely unknown. This study sought to clarify the cross-sectional and longitudinal associations between self-reported marijuana use, and prediabetes (defined as fasting glucose 5.6–5.9 mmol/l, 2 h glucose post OGTT 7.8–11.0 mmol/l or HbA1c 5.7–6.4% [39–47 mmol/mol]) and diabetes. Data from the community-based Coronary Artery Risk Development in Young Adults (CARDIA) study were used to determine marijuana use and the presence of prediabetes and diabetes among participants. The association between marijuana use and the prevalence of prediabetes and diabetes was examined in 3,034 participants at CARDIA examination year 25 (2010–2011), while the incidence of prediabetes and diabetes according to previous marijuana use was assessed in 3,151 individuals who were free from prediabetes/diabetes at year 7 (1992–1993) and who returned for at least one of the four subsequent follow-up examinations over 18 years. The percentage of individuals who self-reported current use of marijuana declined over the course of the study's follow-up. After multivariable adjustment, higher odds of prediabetes were found for individuals who reported current use of marijuana (OR 1.65 [95% CI 1.15, 2.38]) and a lifetime use of 100 times or more (OR 1.49 [95% CI 1.06, 2.11]), compared with individuals who reported never using marijuana. There was no association between marijuana use and diabetes at CARDIA examination year 25. Over 18 years of follow-up, a greater risk of prediabetes (but not diabetes) was found for individuals who reported a lifetime use of marijuana of 100 times of more (HR 1.39 [95% CI 1.13, 1.71]), compared with individuals who had never used marijuana. Marijuana use in young adulthood is associated with an increased risk of prediabetes by middle adulthood, but not with the development of diabetes by this age.