Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega-3 polyunsaturated fatty acids
Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with Omega-3 polyunsaturated fatty acids
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DOI：
10.1111/j.1365-2362.2005.01540.x
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发表时间：
2005-08-01
影响因子：
5.5
通讯作者：
Berra, B
中科院分区：
文献类型：
--
作者：
Fontani, G;Corradeschi, F;Berra, B
研究背景膳食和Omega-3多不饱和脂肪酸被认为是降低心血管疾病和炎症性疾病风险的重要因素，但对健康受试者的影响细节很少。本研究的目的是检查几个生理参数的变化，在健康受试者在不同的饮食补充Omega-3 fatty acids.Materials和方法的实验进行了33名受试者分为4组，根据双盲交叉设计与1：1的比例为Omega-3（与安慰剂）和开放标签平行组，1：1比例的Zone饮食（与意大利国家营养和食品研究所建议的饮食）。在实验开始时以及35天（交叉）和70天后采集血样。的情绪状态测试（POMS）的配置文件也performed.Results的花生四烯酸/二十碳五烯酸的比例（AA/EPA）的强烈下降，欧米茄-3的补充效果的饮食，特别是区饮食。AA/EPA降低与胰岛素和同型半胱氨酸水平的伴随降低相关。Zone饮食减少了皮褶厚度和体脂百分比，也显示了抗氧化作用。补充Omega-3后，情绪状态发生了变化，POMS指数增加。结论饮食和Omega-3对AA/EPA和情绪状态有不同的影响，Zone饮食尤其能降低体脂，而血液指标如甘油三酯/HDL比值、胰岛素和同型半胱氨酸与AA/EPA变化有关。这些研究结果进行了讨论的差异，在组成的饮食和欧米茄-3对生理功能的影响。
Background Diets and Omega-3 polyunsaturated fatty acids have been considered as important factors to reduce the risk of cardiovascular and inflammatory diseases, but there are few details on the effects on healthy subjects. The aim of the present study was to examine the variation of several physiological parameters in healthy subjects on different diets supplemented with Omega-3 fatty acids.Materials and methods The experiment was carried out on 33 subjects divided into four groups according to a double-blind cross-over design with a 1 : 1 ratio for Omega-3 (vs. placebo) and open-label parallel-groups with a 1 : 1 ratio for the Zone diet (vs. the diet suggested by the Italian National Research Institute for Nutrition and Foods). Blood samples were collected at the beginning of the experiment and after 35 (cross-over) and 70 days. The Profile of Mood States test (POMS) was also performed.Results The arachidonic acid/eicosapentaenoic acid ratio (AA/EPA) was strongly reduced by Omega-3 with a supplementary effect of the diet and in particular the Zone diet. The AA/EPA reduction was correlated with a concomitant decrease of insulin and homocysteine levels. The Zone diet reduced skinfold thickness and body fat percentage and also showed antioxidant effects. The mood state changed after Omega-3 supplementation, with an increased POMS index. This was related to a concomitant reduction of AA/EPA and was particularly evident in the Zone diet.Conclusion AA/EPA and mood state are differently influenced by diet and Omega-3, body fat is particularly reduced by Zone diet, while blood parameters such as triglycerides/HDL ratio, insulin and homocysteine are related to AA/EPA variations. These findings are discussed in terms of differences in the composition of the diets and the influences of Omega-3 on physiological functions.