DIFFERENCES IN REJECTION OF SKIN TRANSPLANTS AND BLOOD CELLS OF DONOR MARROW ORIGIN BY RADIATION-INDUCED CHIMERAS
DIFFERENCES IN REJECTION OF SKIN TRANSPLANTS AND BLOOD CELLS OF DONOR MARROW ORIGIN BY RADIATION-INDUCED CHIMERAS
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DOI：
10.1111/j.1749-6632.1962.tb45335.x
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发表时间：
1962-01-01
期刊：
影响因子：
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通讯作者：
CHIN, PH
中科院分区：
文献类型：
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作者：
SILVERMAN, MS;CHIN, PH
在超过50%的长期存活的鼠-鼠嵌合体中，发生了对大鼠皮肤移植物的排斥反应，但对大鼠骨髓来源的循环细胞的排斥反应没有发生。通过暴露于致死剂量的X射线照射，然后通过大鼠骨髓注射诱导嵌合体。发现恢复到完全不耐受状态的小鼠对大鼠红细胞具有高滴度的血凝素。那些只排斥皮肤移植物的动物没有检测到血凝素，尽管有些动物能够形成鼠源性抗体对抗绵羊红细胞。这些发现提供了三种可能的解释。
The rejection of rat skin transplants but not circulating cells of rat bone marrow origin occurred in over 50% of the long-term surviving mouse-rat chimeras. The chimeras were induced by exposure to lethal doses of X-irradiation, followed by rat bone marrow injections. Mice reverting to a completely nontolerant state were found to have a high titer of hemagglutinins to rat red blood cells. Those animals that rejected only the skin grafts had no detectable hemagglutinins, although some were able to form antibodies of mouse origin against sheep red blood cells. Three possible explanations for these findings are offered.