Epithelial cell-derived antimicrobial peptides are multifunctional agents that bridge innate and adaptive immunity.
Epithelial cell-derived antimicrobial peptides are multifunctional agents that bridge innate and adaptive immunity.
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上皮细胞衍生的抗菌肽是弥合先天和适应性免疫的多功能剂。
DOI：
10.1111/j.1600-0757.2010.00373.x
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发表时间：
2010-10
影响因子：
18.6
通讯作者：
Weinberg A
中科院分区：
文献类型：
--
作者：
McCormick TS;Weinberg A
粘膜屏障不仅是物理性的，它们还是有效的抗菌肽的来源。这些古老的化合物对于真核宿主的先天防御是重要的。它们在数小时内对广谱细菌、真菌和包囊病毒发挥作用（综述见（34，94，102））。先天免疫系统与哺乳动物的适应性免疫系统一起工作，允许宿主在感染后不久抑制，延迟或避免微生物生长。例如，人β-防御素，特异性上皮细胞衍生的抗微生物肽（见下文），已显示通过与特异性趋化因子和Toll样受体相互作用与适应性免疫系统“串扰”，导致调节宿主的免疫活性细胞应答（6，27，29，98）。因此，理论上，通过上皮细胞衍生的抗微生物肽的监视功能是使微生物的天然植物群在不同的小生境如皮肤、肠和口腔中保持稳定状态。本综述将重点介绍我们小组和其他人最近的发现，表明抗菌肽不仅是抗菌的;它们在多种功能中与许多细胞类型起交叉作用，如调节上皮细胞增殖，增强伤口愈合，抑制/诱导促炎细胞因子，促进/抑制血管生成，刺激趋化因子产生，促进各种白细胞的趋化性，肥大细胞脱粒或调节宿主细胞基因表达。
Mucosal barriers are not only physical; they are the source of potent antimicrobial peptides. These ancient compounds are important for the innate defense of an eukaryotic host. They function within a matter of hours, on a broad spectrum of bacteria, fungi, and encapsulated viruses (reviewed in (34, 94, 102)). The innate immune system works in conjunction with the adaptive immune system in mammals, by permitting the host to curb, delay, or avoid microbial growth shortly after an infection. For example, human β-defensins, specific epithelial cell-derived antimicrobial peptides (see below), have been shown to “cross-talk” with the adaptive immune system by interacting with specific chemokine and Toll-like receptors, resulting in modulation of immunocompetent cell responses of the host (6, 27, 29, 98). It is theorized therefore, that surveillance through epithelial cell-derived antimicrobial peptides functions to keep the natural flora of microorganisms in a steady state in different niches such as the skin, the intestines, and the mouth. This review will highlight recent findings, by our group and others, demonstrating that antimicrobial peptides are not just antimicrobial; they play an added role of cross-talking with a number of cell types in functions as diverse as regulating epithelial cell proliferation, enhancing wound healing, inhibiting/inducing pro-inflammatory cytokines, promoting/inhibiting angiogenesis, stimulating chemokine production, promoting chemotaxis of various leukocytes, degranulating mast cells or modulating host cell gene expression.
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影响因子：
3.5
作者：
Borregaard, Niels;Cowland, Jack B.
通讯作者：
Cowland, Jack B.
DOI：
10.1073/pnas.88.9.3952
发表时间：
1991-05-01
影响因子：
11.1
作者：
DIAMOND, G;ZASLOFF, M;BEVINS, CL
通讯作者：
BEVINS, CL
DOI：
10.1073/pnas.0900244106
发表时间：
2009-03-10
影响因子：
11.1
作者：
Coffelt, Seth B.;Marini, Frank C.;Scandurro, Aline B.
通讯作者：
Scandurro, Aline B.
影响因子：
4.8
作者：
Frohm, M;Agerberth, B;Gudmundsson, GH
通讯作者：
Gudmundsson, GH
影响因子：
24.5
作者：
Bajaj-Elliott, M;Fedeli, P;Farthing, MJG
通讯作者：
Farthing, MJG