THE ROLE OF BRAIN SEROTONIN IN DDT‐INDUCED HYPERPYREXTA
THE ROLE OF BRAIN SEROTONIN IN DDT‐INDUCED HYPERPYREXTA
复制标题
脑血清素在滴滴涕引起的高热中的作用
作者：
D. Peters;P. Hrdina;R. Singhal;G. Ling
摘要：对大鼠给予单剂量p，p′-DDT导致脑干中5-羟基吲哚乙酸浓度显著增加。用该杀虫剂处理后，未观察到5-羟色胺（5-羟色胺）的量发生显著变化。然而，与单胺氧化酶抑制剂单独给药相比，当给予帕吉林治疗的大鼠p，p′-DDT时，观察到5-羟色胺显著增加。同时给予p，p′-DDT和dl-p-氯苯丙氨酸不仅阻断了观察到的5-羟基吲哚乙酸的升高，而且几乎完全抑制了杀虫剂引起的神经毒性症状（高热、震颤和惊厥）。相比之下，DL-6-氟色氨酸（一种更特异的5-羟色胺合成抑制剂）可防止DDT诱导的体温升高以及羟吲哚乙酸的增加，但不影响震颤和惊厥的发生。我们的数据表明，脑5-羟色胺周转率的增加可能是p，p′-DDT引起的高热的基础。
Abstract— Administration of a single dose of p,p′‐DDT to rats resulted in a marked increase in the concentration of 5‐hydroxyindoleacetic acid in the brain stem. No significant change was observed in the amount of 5‐hydroxytryptamine (serotonin) following treatment with this insecticide. However, when p,p′‐DDT was given to pargyline‐treated rats, a significantly greater increase in serotonin was observed when compared to that with the monoamine oxidase inhibitor alone. The concomitant administration of p,p′‐DDT and dl‐p‐chlorophenylalanine not only blocked the observed rise in 5‐hydroxyindoleacetic acid but also suppressed almost completely the neurotoxic symptoms (hyperpyrexia, tremors and convulsions) seen with the pesticide. In contrast, DL‐6‐fluorotryptophan (a more specific inhibitor of serotonin synthesis) prevented the DDT‐induced rise in body temperature as well as the increase in hydroxyindoleacetic acid, but did not affect the occurrence of tremor and convulsions. Our data suggest that an increase in the turnover rate of brain serotonin may underlie the hyperpyrexia induced by p,p′‐DDT.