Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas
Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas
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DOI：
10.1007/978-94-007-6088-2
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发表时间：
2013
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影响因子：
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通讯作者：
R. Chakraborty
中科院分区：
文献类型：
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作者：
R. Chakraborty
铁对大多数细菌的生长是必不可少的，因为它是重要酶的辅助因子，也是电子传递链的组成部分。此外，铁在细菌致病性中起重要作用；事实上，细菌中的铁转运系统可以作为设计新型抗生素的靶点。因为铁在有氧条件下不能溶解，细菌必须找到克服缺铁的方法。其中一种是产生一种叫做铁载体的铁螯合小有机分子。事实上，大多数细菌和真菌产生结构和化学上多样化的铁载体，这些铁载体通过复杂的能量依赖运输系统被运输回细胞质。大肠杆菌和假单胞菌是最先进行检测的；然而，现在已经研究了许多其他细菌的铁转运系统。以大肠杆菌和假单胞菌为重点，综述了细菌铁转运系统研究的最新进展。第一章专门介绍迪克·范德·赫尔姆博士对铁载体生物学领域的贡献。然后描述和讨论了大肠杆菌中铁载体介导的铁转运系统的组成和机制的结构进展。第2章详细介绍革兰氏阴性菌和革兰氏阳性菌的铁转运和铁调节系统。最后，第三章介绍了假单胞菌的铁转运系统。这本书是针对研究人员在多个生物体的铁代谢领域，并对那些有兴趣研究细菌的铁运输系统。它也吸引着研究蛋白质结构和功能关系的科学家。
Iron is essential for the growth of most bacteria because it serves as a cofactor for vital enzymes and for the components of the electron transport chain. Moreover, Iron plays an important role in bacterial pathogenicity; in fact, the iron transport systems in bacteria works as target for designing novel antibiotics. Because iron is not soluble under aerobic conditions, bacteria have had to find ways to overcome iron deficiency. One of them is producing an iron-chelating small organic molecule called siderophore. Indeed, most bacteria and fungi produce structurally and chemically diverse siderophores which are transported back to the cytoplasm using complex energy dependent transport systems. Escherichia coli and Pseudomonas were the first ones to be tested; however, nowadays iron transport systems have been investigated in many other bacteria. Iron Uptake in Bacteria with Emphasis on E. coli and Pseudomonas reviews the recent advancements in the field of iron transport systems in bacteria. Chapter 1 is dedicated to Dr. Dick van der Helm’s contribution to the field of siderophore biology. It then describes and discusses the structural advances in the components and the mechanism of siderophore mediated iron transport systems in E. coli. Chapter 2 details the variety of iron transport and iron regulatory systems of both gram negative and gram positive bacteria. Finally, chapter 3 describes the iron transport systems of Pseudomonas. This book is aimed at researchers in the fields of iron metabolism in multiple organisms, and to those who are interested in studying iron transport systems of bacteria. It appeals also to scientists researching structure and function relationship of proteins.