NLR functions beyond pathogen recognition
NLR functions beyond pathogen recognition
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DOI：
10.1038/ni.1985
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发表时间：
2011-02-01
影响因子：
30.5
通讯作者：
Sansonetti, Philippe J.
中科院分区：
文献类型：
--
作者：
Kufer, Thomas A.;Sansonetti, Philippe J.
在过去的10年里，人们发现了一类新的细胞内模式识别分子--核苷酸结合域和富含亮氨酸重复序列的家族(NLR)。这个家族的成员作为能够触发对病原体的炎症反应的模式识别受体而引起了人们的兴趣。许多研究支持人类NLR蛋白的病原体识别功能，并阐明了它们在适应性免疫和各种疾病状态的更广泛控制中的作用。其他证据表明，NLRs在与病原体检测无关的过程中发挥作用。在这里，我们讨论了人类NLR蛋白的生物学及其在组织内稳态、细胞凋亡、移植物抗宿主病和早期发育中的非病原体识别功能的最新进展。
The last 10 years have witnessed the identification of a new class of intracellular pattern-recognition molecules-the nucleotide-binding domain and leucine-rich repeat-containing family (NLR). Members of this family garnered interest as pattern-recognition receptors able to trigger inflammatory responses against pathogens. Many studies support a pathogen-recognition function for human NLR proteins and shed light on their role in the broader control of adaptive immunity and various disease states. Other evidence suggests that NLRs function in processes unrelated to pathogen detection. Here we discuss recent advances in our understanding of the biology of the human NLR proteins and their non-pathogen-recognition function in tissue homeostasis, apoptosis, graft-versus-host disease and early development.