Activation of keratinocyte-mediated collagen (type I) breakdown by suspected human periodontopathogen. Evidence of a novel mechanism of connective tissue breakdown.

Activation of keratinocyte-mediated collagen (type I) breakdown by suspected human periodontopathogen. Evidence of a novel mechanism of connective tissue breakdown.
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疑似人类牙周病原体激活角质形成细胞介导的胶原蛋白(I 型)分解。

DOI:
10.1111/j.1600-0765.1984.tb01333.x
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发表时间:
1984
影响因子:
3.5
通讯作者:
Taylor,RE
Taylor,RE
中科院分区:
医学3区
文献类型:
--
作者:
Birkedal-Hansen,H;Wells,BR;Lin,HY;Caufield,PW;Taylor,RE

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微生物病原体在牙周疾病发展中的主要作用已有很好的文献记载,但将微生物定植转化为牙周胶原纤维的偶发性溶解的细胞机制知之甚少。在患有破坏性牙周病的患者中,龈沟上皮首先受到前进的微生物植物群的产物的影响,并且携带微生物影响的可见溃疡和增殖证据。本文报告了一个分析上皮胶原溶解反应的微生物来源于口腔。
The principal role of microbial pathogens in the development of periodontal diseases is well documented, but the cellular mechanisms which translate microbial colonization into episodic dissolution of periodontal collagen fibers are poorly understood. In patients with destructive periodontal diseases the crevicular epithelium is first affected by products of the advancing microbial flora and carries visible ulcerative and proliferative evidence of microbial influences. The paper reports an analysis of epithelial collagenolytic responses to microorganisms derived from the oral cavity.
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