Medial temporal lobe neuromagnetic hypoactivation and risk for developing cognitive decline in elderly population:: A 2-year follow-up study
Medial temporal lobe neuromagnetic hypoactivation and risk for developing cognitive decline in elderly population:: A 2-year follow-up study
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DOI：
10.1016/j.neurobiolaging.2005.01.005
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发表时间：
2006-01-01
影响因子：
4.2
通讯作者：
Ortiz, T
中科院分区：
文献类型：
--
作者：
Maestú, F;Campo, P;Ortiz, T
认知能力随着年龄的增长而下降。然而，一些长者可能会出现更严重的状况，例如轻度认知障碍（MCI）。本研究的目的是早期检测大脑活动的神经生理学模式，这可以预测某些受试者发生 MCI 的可能性。通过脑磁图记录 15 名健康受试者在记忆任务期间的脑磁活动。在第一次临床评估时，没有任何参与者可以被视为 MCI。经过 2 年的随访，5 名受试者出现了 MCI，10 名受试者在一段时间内保持了认知状态。与非认知衰退组相比，出现认知衰退的受试者在刺激开始后 400 至 800 毫秒之间左内侧颞叶的活动源数量较少。这些发现可能有助于早期识别认知能力下降高风险的老年受试者，从而有可能进行神经心理学或药物治疗，从而延缓或预防认知障碍的进展。 (C) 2005 Elsevier Inc. 保留所有权利。
Cognition declines as a function of age. However, some elders could develop more severe status such as mild cognitive impairment (MCI). The aim of this study was the early detection of neurophysiological patterns of brain activity that may predict the possibility of certain subjects to develop MCI. Brain magnetic activity was recorded from 15 healthy subjects during a memory task by means of magnetoencephalography. None of the participants could be considered as MCI at the time of the first clinical evaluation. After 2-year follow-up, five subjects developed MCI and 10 maintained their cognitive status across time. The subjects who developed cognitive decline showed a lower number of activity sources in the left medial temporal lobe between 400 and 800 ms after stimulus onset, as compared to the non-cognitive decline group. These findings may help with the early identification of elderly subjects at high risk of cognitive decline, allowing the possibility of neuropsychological or pharmaceutical treatment that delay or prevent the progression of the cognitive impairment. (C) 2005 Elsevier Inc. All rights reserved.