Ulcerative colitis and colon cancer: Biology and surveillance
Ulcerative colitis and colon cancer: Biology and surveillance
复制标题
溃疡性结肠炎和结肠癌：生物学和监测
DOI：
--
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
B. Levin
中科院分区：
文献类型：
--
作者：
B. Levin
长期溃疡性结肠炎和克罗恩病患者患结肠直肠癌的风险增加。炎症性肠病中癌症的发展被假设为通过涉及遗传不稳定性、克隆扩增和恶性表型的发展的多步骤过程而演变。叶酸缺乏等营养因素的作用引起了极大的兴趣;分子遗传机制正在研究中。与散发性结直肠癌相反，溃疡性结肠炎中的癌与长期的慢性炎症病史和随后的上皮发育不良有关。异型增生定义为结肠粘膜明确的肿瘤性改变。监测的目的是通过在癌前或早期可治愈阶段进行检测，预防癌症死亡。通常接受内窥镜监测的癌症风险最高的患者是那些患有持续时间超过8年的广泛结肠炎的患者。发育不良的上皮可能发生在平坦的粘膜中，并可能产生斑块或结节状/绒毛状外观。并不是所有结肠癌患者都存在异型增生。重要的是开发更敏感和特异性的标记物，用于结肠炎中癌前病变或癌症的存在。正在研究的是通过免疫组织化学、凝集素结合、流式细胞术和激光诱导荧光结合内窥镜检测的增殖相关标志物。© 1992 Wiley利斯公司
The risk of colorectal carcinoma is increased among patients with longstanding ulcerative colitis and Crohn's disease. The development of cancer in inflammatory bowel disease is hypothesized to evolve by a multistep process involving genetic instability, clonal expansion and the development of a malignant phenotype. The contribution of nutritional factors such as folate deficiency is of great interest; molecular genetic mechanisms are under study. In contrast to sporadic colorectal carcinoma, carcinomas in ulcerative colitis are associated with a long prior history of chronic inflammation and the subsequent development of epithelial dysplasia. Dysplasia is defined as an unequivocal neoplastic alteration of the colonic mucosa. The object of surveillance is prevention of death from cancer by detection at a premalignant or early curable stage. Patients at greatest risk of cancer who customarily undergo endoscopic surveillance are those with extensive colitis of more than 8 years duration. Dysplastic epithelium may occur in flat mucosa, and may produce a plaque or a nodular/villiform appearance. Dysplasia is not present in all patients with cancer in colitis. It is important to develop more sensitive and specific markers for the presence of precancer or cancer in colitis. Under study are proliferation‐associated markers detected by immunohistochemistry, lectin binding, flow cytometry and laser‐induced fluorescence coupled with endoscopy. © 1992 Wiley‐Liss, Inc.
通过聚合酶链式反应产物的直接测序测定人胃肠道发育不良中 c-Ki-ras 的激活。
影响因子：
11.2
作者：
Meltzer,SJ;Mane,SM;Wood,PK;Resau,JH;Newkirk,C;Terzakis,JA;Korelitz,BI;Weinstein,WM;Needleman,SW
通讯作者：
Needleman,SW
使用尾苋的凝集素作为增殖结肠上皮细胞的组织化学探针。
影响因子：
11.2
作者：
Boland,CR;Chen,YF;Rinderle,SJ;Resau,JH;Luk,GD;Lynch,HT;Goldstein,IJ
通讯作者：
Goldstein,IJ