Time course of nodal enhancement with CT x-ray nanoparticle contrast agents - Effect of particle size and chemical structure
Time course of nodal enhancement with CT x-ray nanoparticle contrast agents - Effect of particle size and chemical structure
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DOI：
10.1097/00004424-200002000-00001
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发表时间：
2000-02-01
影响因子：
6.7
通讯作者：
Wolf, GL
中科院分区：
文献类型：
--
作者：
McIntire, GL;Bacon, ER;Wolf, GL
基本原理和目标。在兔皮下注射四种碘化不溶性纳米造影剂后，观察其淋巴结CT增强水平随时间的变化，为这些造影剂的清除与造影剂本身的化学结构有关的假设提供实验支持。研究了粒径的影响。在兔爪背皮下注射4种纳米造影剂的15%混悬液（2 × 0.25 mL）。分别于注射后4、10、24、48、72小时及5、7、14天获得图像。从每个时间点每个淋巴结的CT扫描中估计平均衰减（Hounsfield单位[HU]）、淋巴结体积和总碘摄取。所有药物均对兔的腘窝和腋窝淋巴结（即> Delta 100 HU）有充分的增强作用。淋巴结体积似乎与增强的持久性有关，长效剂表现出最大的体积增加。淋巴结清除率与药物的结构有关。不溶性碘化纳米造影剂从淋巴结的清除可以通过改变造影剂本身的结构来调节。使用同样的药剂，更小的颗粒可以更快地将物质输送到淋巴结，更快地清除。
RATIONALE AND OBJECTIVES. Levels of CT enhancement in rabbit lymph nodes were followed with time after subcutaneous injection of four iodinated, insoluble nanoparticle contrast agents to provide experimental support for the hypothesis that clearance of these agents is related to the chemical structure of the agent itself. The impact of particle size was also studied,METHODS. Subcutaneous injections (2 x 0.25 mL) were made in the dorsum of rabbit paws with 15% suspensions of four nanoparticle contrast agents. Images were obtained at 4, 10, 24, 48, and 72 hours and 5, 7, and 14 days after injection. Average attenuation (in Hounsfield units [HU]), node volume, and total iodine uptake were estimated from the CT scans for each lymph node at each time point,RESULTS. All the agents provided adequate enhancement of both the popliteal and axillary lymph nodes of the rabbit (ie, > Delta 100 HU). Lymph node volume appears to be related to the persistence of enhancement, with long-lived agents demonstrating the greatest increase in size. The rate of clearance from the lymph nodes is related to the structure of the agent.CONCLUSIONS. Clearance of insoluble, iodinated nanoparticle contrast agents from lymph nodes can be modulated by changes in the structure of the agent itself. Using the same agent, smaller particles deliver material to the lymph nodes more quickly and clear more quickly.