Viscoelastic properties of liver measured by oscillatory rheometry and multifrequency magnetic resonance elastography
Viscoelastic properties of liver measured by oscillatory rheometry and multifrequency magnetic resonance elastography
复制标题
DOI：
10.3233/bir-2010-0565
复制
发表时间：
2010-01-01
期刊：
影响因子：
1.1
通讯作者：
Sack, Ingolf
中科院分区：
文献类型：
--
作者：
Klatt, Dieter;Friedrich, Christian;Sack, Ingolf
肝脏的力学性质可以敏感地反映肝纤维化的进展。机械组织表征涉及通过振荡流变仪或通过体内弹性成像测量的复合剪切模量的分析。在这项研究中，牛肝标本进行了研究，振荡流变仪和多频磁共振弹性成像（MRE）在一个共同的频率范围在25.0和62.5 Hz之间。并与人肝的活体MRE进行了比较。对储存模量和损耗模量进行了量化，并采用弹簧模型对数据进行了分析，通过流变仪在牛肝脏中获得了2.96 +/- 0.53 kPa的刚度相关参数，通过体内MRE在人肝脏中获得了2.20 +/- 0.45 kPa的刚度相关参数。此外，离体牛肝的MRE表明，刚度往往随着样品温度的降低而增加。总之，多频磁共振成像的机械组织表征与振荡流变学一致，这验证了磁共振成像作为一种研究肝组织流变学的方法。
The mechanical properties of liver can sensitively indicate the progression of hepatic fibrosis. Mechanical tissue characterization involves the analysis of the complex shear modulus measured either by oscillatory rheometry or by in vivo elastography. In this study, bovine liver specimens were investigated by oscillatory rheometry and multifrequency magnetic resonance elastography (MRE) in a common frequency range between 25.0 and 62.5 Hz. The results were compared with in vivo MRE of human liver. Storage and loss moduli were quantified, and the data were also analyzed employing a springpot model, yielding a stiffness-related parameter of 2.96 +/- 0.53 kPa in bovine liver by rheometry and of 2.20 +/- 0.45 kPa in human liver by in vivo MRE. Furthermore, MRE of excised bovine liver showed that stiffness tended to increase with decreasing sample temperature. In conclusion, mechanical tissue characterization by multifrequency MRE agrees well with oscillatory rheometry, which validates MRE as a method for investigating the rheology of liver tissue.