Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine
Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine
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DOI：
10.1111/j.1468-2982.2008.01816.x
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发表时间：
2009-08-01
期刊：
影响因子：
4.9
通讯作者：
Chiou, L-C
中科院分区：
文献类型：
--
作者：
Fan, P-C;Kuo, P-H;Chiou, L-C
为了探讨血浆降钙素基因相关肽（CGRP）在儿童偏头痛中的作用，我们前瞻性地收集了134份4-18岁的偏头痛患者（66例）、非偏头痛患者（33例）和非头痛患者（22例）的发作期间或发作之间的血液样本。采用酶联免疫吸附法测定血浆CGRP浓度，采用儿童偏头痛残疾评估（PedMIDAS）问卷测定残疾程度。偏头痛患者血浆CGRP水平高于非偏头痛患者（P = 0.007）。偏头痛患者的发作水平高于非发作水平（P = 0.036），但非偏头痛患者的发作水平不高于非发作水平。配对比较也显示了这一点（n = 9，P = 0.015 vs. n = 4，P = 0.47）。使用55.1 pg/ml的阈值，预测偏头痛发作水平的敏感性为0.81，特异性为0.75。采用Mann-Whitney检验，高CGRP组（> 200 pg/ml，n = 7）的PedMIDAS评分倾向于高于低CGRP组（< 200 pg/ml，n = 33）（26.07 vs. 19.32，P = 0.16）。血浆降钙素基因相关肽对儿童偏头痛的诊断有一定价值。
To investigate the role of plasma calcitonin gene-related peptide (CGRP) in paediatric migraine, we prospectively collected 134 blood samples during or between attacks from 66 migraine, 33 non-migraine headache (non-migraine) and 22 non-headache patients, aged 4-18 years. Plasma CGRP concentrations were measured by enzyme-linked immunosorbent assay and disability by Pediatric MIgraine Disability ASsessment (PedMIDAS) questionnaire. Migraineurs had higher plasma CGRP levels than non-migraine patients (P = 0.007). The attack level was higher than the non-attack level in migraine (P = 0.036), but not in non-migraine, patients. This was also revealed in paired comparison (n = 9, P = 0.015 vs. n = 4, P = 0.47). Using a threshold of 55.1 pg/ml, the sensitivity of the attack level in predicting migraine was 0.81, and specificity 0.75. The PedMIDAS score tended to be higher in the high CGRP (> 200 pg/ml, n = 7) group than in the low (< 200 pg/ml, n = 33) group (26.07 vs. 19.32, P = 0.16) using Mann-Whitney test. Plasma CGRP is useful for diagnosis in paediatric migraine.