Bleeding Complications in Patients with Hematologic Malignancies
Bleeding Complications in Patients with Hematologic Malignancies
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DOI：
10.1055/s-0032-1331154
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发表时间：
2013-02-01
影响因子：
5.7
通讯作者：
Bonfanti, Carlo
中科院分区：
文献类型：
--
作者：
Franchini, Massimo;Frattini, Francesco;Bonfanti, Carlo
血液恶性肿瘤患者经常遇到止血异常，导致出血性和血栓性不良事件。对这些患者的发病率和死亡率产生负面影响的并发症的及时识别和处理对血液学家来说是一个重大挑战。本综述描述了血液恶性肿瘤出血相关的止血最重要的变化，特别强调其病因、复杂的致病机制、临床表现和治疗策略。特别讨论了血小板和获得性凝血异常、急性白血病的出血并发症以及造血干细胞移植。
Abnormalities of hemostasis are frequently encountered in patients with hematologic malignancies leading to both hemorrhagic and thrombotic adverse events. The prompt recognition and management of such complications, which have a negative impact on the morbidity and mortality of these patients, represents a major challenge for hematologists. This review describes the most important changes of hemostasis associated with hemorrhage in hematologic malignancies with particular emphasis on their contributory etiologic factors, complex pathogenic mechanisms, clinical manifestations, and therapeutic strategies. In particular, platelet and acquired coagulation abnormalities, bleeding complications in acute leukemia, and hematopoietic stem cell transplantation are discussed.