T-cell dysregulation in COVID-19.
T-cell dysregulation in COVID-19.
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DOI：
10.1016/j.bbrc.2020.10.079
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发表时间：
2021-01-29
影响因子：
3.1
通讯作者：
Ono M
中科院分区：
文献类型：
--
作者：
Kalfaoglu B;Almeida-Santos J;Tye CA;Satou Y;Ono M
T细胞在对COVID-19的免疫以及严重疾病的发展中起着关键作用。对COVID-19的T细胞免疫是通过分化的CD 4 + T细胞和细胞毒性CD 8 + T细胞介导的，尽管它们的分化在COVID-19中通常是非典型和模糊的，并且关键基因的单细胞动力学需要表征。值得注意的是，重症COVID-19患者的T细胞失调，尽管其分子特征尚未完全揭示。重要的是，目前尚不清楚哪些T细胞活动是有益的和保护性的，哪些T细胞活动可能导致严重的COVID-19的发展。在这篇文章中，我们研究了最新的证据，并讨论了COVID-19中T细胞反应的关键特征，显示了T细胞在严重的COVID-19患者中是如何失调的。特别是，我们强调了CD 4 + T细胞中FOXP 3诱导的损伤，以及受损的FOXP 3表达如何导致严重患者异常活化（过度活化）T细胞的分化和失调的T细胞反应。此外，我们研究了过度活化的T细胞的特征，显示了它们在COVID-19中对T细胞失调和免疫介导的组织破坏（免疫病理学）的潜在贡献。
T-cells play key roles in immunity to COVID-19 as well as the development of severe disease. T-cell immunity to COVID-19 is mediated through differentiated CD4+ T-cells and cytotoxic CD8+ T-cells, although their differentiation is often atypical and ambiguous in COVID-19 and single cell dynamics of key genes need to be characterized. Notably, T-cells are dysregulated in severe COVID-19 patients, although their molecular features are still yet to be fully revealed. Importantly, it is not clear which T-cell activities are beneficial and protective and which ones can contribute to the development of severe COVID-19. In this article, we examine the latest evidence and discuss the key features of T-cell responses in COVID-19, showing how T-cells are dysregulated in severe COVID-19 patients. Particularly, we highlight the impairment of FOXP3 induction in CD4+ T-cells and how the impaired FOXP3 expression can lead to the differentiation of abnormally activated (hyperactivated) T-cells and the dysregulated T-cell responses in severe patients. Furthermore, we characterise the feature of hyperactivated T-cells, showing their potential contribution to T-cell dysregulation and immune-mediated tissue destruction (immunopathology) in COVID-19.
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影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
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影响因子：
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影响因子：
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