Sympathetic hyperactivity in chronic kidney disease: Pathogenesis, clinical relevance, and treatment
Sympathetic hyperactivity in chronic kidney disease: Pathogenesis, clinical relevance, and treatment
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DOI：
10.1111/j.1523-1755.2004.00552.x
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发表时间：
2004-05-01
影响因子：
19.6
通讯作者：
Blankestijn, PJ
中科院分区：
文献类型：
--
作者：
Neumann, J;Ligtenberg, G;Blankestijn, PJ
心血管疾病的发病率和死亡率对慢性肾脏病（CKD）患者的预期寿命有重要影响。传统的风险因素通常存在，但最近发现了其他几个因素。现在有证据表明，CKD通常以激活的交感神经系统为特征。这可能有助于肾性高血压的发病机制，但它也可能对预后产生不利影响，独立于其对血压的影响。本文综述了交感神经系统在肾性高血压发病机制中的作用，其临床意义，以及这些知识对治疗选择的影响。
Cardiovascular morbidity and mortality importantly influence live expectancy of patients with chronic renal disease (CKD). Traditional risk factors are usually present, but several other factors have recently been identified. There is now evidence that CKD is often characterized by an activated sympathetic nervous system. This may contribute to the pathogenesis of renal hypertension, but it may also adversely affect prognosis independently of its effect on blood pressure. The purpose of this review is to summarize available knowledge on the role of the sympathetic nervous system in the pathogenesis of renal hypertension, its clinical relevance, and the consequences of this knowledge for the choice of treatment.