Accumulation and Enrichment of Trace Elements by Yeast Cells and Their Applications: A Critical Review.
Accumulation and Enrichment of Trace Elements by Yeast Cells and Their Applications: A Critical Review.
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酵母细胞对微量元素的积累和富集及其应用：综述
DOI：
10.3390/microorganisms10091746
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发表时间：
2022-08-30
期刊：
影响因子：
4.5
通讯作者：
中科院分区：
文献类型：
--
作者：
维持微量元素的体内平衡对生物体的健康至关重要。由于缺乏微量元素而引起的疾病威胁着人类的健康。酿酒酵母与人类的日常生活和工业应用有着广泛而密切的关系。它不仅可以作为发酵产物和单细胞蛋白，还可以作为微量元素补充剂，广泛应用于食品、饲料、医药等领域。富含微量元素的酵母，即富含铬、铁、锌和硒的酵母，作为一种有效的微量元素补充剂，比无机和有机酵母更有效、更环保、更安全。在过去的几十年里，基因工程已经在酵母中进行了大规模的基因重新设计和重建。人们希望工程酵母能含有更高浓度的微量元素。在这篇综述中，我们比较了几种关键微量元素的常见补充形式。本文还对酵母中微量元素的解毒和转运机制进行了综述。并对参与微量元素转运和解毒的基因进行了综述。探讨了酿酒酵母代谢工程转化生产富微量元素酵母的可行途径。此外，对工程酵母的经济性、安全性和环保性进行了探讨，并对未来富微量元素酵母的研究方向进行了探讨。
Maintaining the homeostasis balance of trace elements is crucial for the health of organisms. Human health is threatened by diseases caused by a lack of trace elements. Saccharomyces cerevisiae has a wide and close relationship with human daily life and industrial applications. It can not only be used as fermentation products and single-cell proteins, but also as a trace elements supplement that is widely used in food, feed, and medicine. Trace-element-enriched yeast, viz., chromium-, iron-, zinc-, and selenium-enriched yeast, as an impactful microelements supplement, is more efficient, more environmentally friendly, and safer than its inorganic and organic counterparts. Over the last few decades, genetic engineering has been developing large-scaled genetic re-design and reconstruction in yeast. It is hoped that engineered yeast will include a higher concentration of trace elements. In this review, we compare the common supplement forms of several key trace elements. The mechanisms of detoxification and transport of trace elements in yeast are also reviewed thoroughly. Moreover, genes involved in the transport and detoxification of trace elements are summarized. A feasible way of metabolic engineering transformation of S. cerevisiae to produce trace-element-enriched yeast is examined. In addition, the economy, safety, and environmental protection of the engineered yeast are explored, and the future research direction of yeast enriched in trace elements is discussed.
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影响因子：
7.4
作者：
Cobbett, CS
通讯作者：
Cobbett, CS
影响因子：
4.5
作者：
Batic, M;Raspor, P
通讯作者：
Raspor, P
DOI：
10.1016/j.jtemb.2021.126759
发表时间：
2021-04-16
影响因子：
3.5
作者：
Bian, Jiang;Wang, Lingyun;Wu, Xiaobin
通讯作者：
Wu, Xiaobin
DOI：
10.1080/15401420391434333
发表时间：
2003-04-01
期刊：
Nonlinearity in biology, toxicology, medicine
影响因子：
--
作者：
Gaddipati, Jaya P;Rajeshkumar, N V;Jonas, Wayne B
通讯作者：
Jonas, Wayne B
影响因子：
8.4
作者：
Curran, Kathleen A.;Karim, Ashty S.;Gupta, Akash;Alper, Hal S.
通讯作者：
Alper, Hal S.