Isoechinulin-type alkaloids, variecolorins A-L, from halotolerant Aspergillus variecolor
Isoechinulin-type alkaloids, variecolorins A-L, from halotolerant Aspergillus variecolor
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异紫萼苷型生物碱，variecolorins A-L，来自耐盐曲霉
DOI：
10.1021/np070208z
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发表时间：
2007-10-01
影响因子：
5.1
通讯作者：
Zhu, Wei-Ming
中科院分区：
文献类型：
--
作者：
Wang, Wen-Liang;Lu, Zhen-Yu;Zhu, Wei-Ming
从耐盐真菌杂色曲霉（Aspergillusvariecolor）发酵液中分离得到12个新化合物，即杂色曲霉素A-L（1-12）和11个已知类似物（13-23）。化合物1-12的结构经化学和光谱方法确定。化合物1-11、13-15和20-23对DPPH表现出弱的自由基清除活性，IC 50值为43 - 103 μ M。新化合物1-12对P388、HL-60、BEL-7402和A-549细胞系基本上无毒性，IC 50值为70 - 260 μ M。
Twelve new compounds, variecolorins A-L (1-12), together with eleven known analogues (13-23) were isolated from the broth of a halotolerant fungus, Aspergillus variecolor. The structures of compounds 1-12 were determined by chemical and spectroscopic methods. Compounds 1-11, 13-15, and 20-23 exhibited weak radical scavenging activity against DPPH, with IC50 values from 43 to 103,mu M. The new compounds 1-12 all were essentially nontoxic against the P388, HL-60, BEL-7402, and A-549 cell lines with IC50 values from 70 to 260 mu M.