Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma.
Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma.
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DOI：
10.1038/bjc.1997.540
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发表时间：
1997
影响因子：
8.8
通讯作者：
Joensuu H
中科院分区：
文献类型：
--
作者：
Toikkanen S;Pylkkänen L;Joensuu H
对 217 名患有浸润性小叶癌 (ILC) 的女性和 1121 名患有乳腺浸润性导管癌 (IDC) 的女性的结果和预后因素进行了比较。对患者进行了10-43年的随访。 ILC 女性的腋窝淋巴结转移频率低于 IDC 女性（43% vs 53%，P = 0.02），尽管两组之间的原发肿瘤大小没有差异。 ILC 更常见为低级，有丝分裂计数较低，肿瘤坏死较少。此外，与 IDC 相比，ILC 具有较低的 S 期分数，并且在流式细胞术分析中更常见的是 DNA 二倍体（所有比较 P < 0.0001）。 ILC 女性的 5 年和 30 年校正生存率分别为 78% 和 50%，而 IDC 女性的 5 年和 30 年校正生存率分别为 63% 和 37% (P = 0.001)。小型 pT1NOMO ILC (n = 41) 的 10 年校正生存率为 100%，20 年校正生存率为 83%。在多变量分析中，原发肿瘤较大、存在腋窝淋巴结转移、高有丝分裂计数和肿瘤坏死的存在都对 ILC 具有独立的预后价值。我们得出的结论是，ILC 比 IDC 具有更好的生存率。
The outcome and prognostic factors of 217 women with invasive lobular carcinoma (ILC) and those of 1121 women with invasive ductal carcinoma (IDC) of the breast were compared. The patients were followed up for 10-43 years. Women with ILC had axillary nodal metastases less frequently than those with IDC (43% vs 53%, P = 0.02), although there was no difference in the primary tumour size between the groups. ILCs were more frequently of low grade, had lower mitotic counts and had less tumour necrosis. Furthermore, ILCs had lower S-phase fractions and were more often DNA diploid in flow cytometric analysis than IDCs (P < 0.0001 for all comparisons). The 5- and 30-year corrected survival rates of women with ILC were 78% and 50%, respectively, compared with 63% and 37% for women with IDC (P = 0.001). Small pT1NOMO ILCs (n = 41) had 100% 10-year and 83% 20-year corrected survival rates. In a multivariate analysis, a large primary tumour size, the presence of axillary nodal metastases, a high mitotic count and the presence of tumour necrosis all had an independent prognostic value in ILC. We conclude that ILC is associated with better survival than IDC.