THE INFLUENCE OF POTASSIUM AND CHLORIDE IONS ON THE MEMBRANE POTENTIAL OF SINGLE MUSCLE FIBRES
THE INFLUENCE OF POTASSIUM AND CHLORIDE IONS ON THE MEMBRANE POTENTIAL OF SINGLE MUSCLE FIBRES
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DOI：
10.1113/jphysiol.1959.sp006278
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发表时间：
1959-01-01
影响因子：
5.5
通讯作者：
HOROWICZ, P
中科院分区：
文献类型：
--
作者：
HODGKIN, AL;HOROWICZ, P
当[K]o和[Cl]0以恒定的乘积倒数变化时，或者在无氯溶液中改变[K]o时，蛙肌纤维的膜电位变化规律与钾电极相同。在[K]o不变的情况下，[Cl]0的变化不会引起膜电位的永久位移，但存在较大的瞬时变化。在[Cl]0不变的情况下，[K]o从2.5 mm增加到10 mm时，产生突然的去极化，然后缓慢地漂移到平衡值。通过用蔗糖改变外部渗透压来改变内部氯浓度，可以改变负载氯的纤维的膜电位，就像氯电极所期望的那样。这些数据和其他数据是在假设一个Boyle-Conway类型的Donnan系统的基础上解释的。
The membrane potential of frog muscle fibers varied in the same manner as a potassium electrode when [K]o and [Cl]0 were changed reciprocally at constant product, or if [K]o was altered in Cl-free solutions. At constant [K]o, variation of [Cl]0 produced no permanent displacement of membrane potential, but there were large transient changes. At constant [Cl]0, increasing [K]o from 2.5 to 10 mM produced a sudden depolarization and then a slow drift to an equilibrium value. Varying the internal chloride concentration, by altering the external osmotic pressure with sucrose, changed the membrane potential of a fiber loaded with Cl in the manner expected for a chloride electrode. These and additional data are explained on the basis of assuming a Donnan system of the Boyle-Conway type.