Modeling human craniofacial disorders in Xenopus.
Modeling human craniofacial disorders in Xenopus.
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DOI：
10.1007/s40139-017-0128-8
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发表时间：
2017-03
影响因子：
--
通讯作者：
Saint-Jeannet JP
中科院分区：
文献类型：
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作者：
Dubey A;Saint-Jeannet JP
颅面部疾病是人类最常见的出生缺陷之一，给医疗保健和社会带来了巨大的负担。动物模型的发展有助于研究颅面生物学的基本问题，这一知识对于理解这些疾病的病因和发病机制至关重要。绝大多数颅面疾病是由神经脊的异常发育引起的，神经脊是一种多能和迁移的细胞群体。因此，确定这些疾病的发病机制首先要深入了解支配神经脊形成的机制及其在颅面发育中的作用。本文综述了利用非洲爪哇胚胎模拟人类颅面状况的几项研究，并强调了该系统在揭示与人类颅面发育和疾病相关的重要生物学过程方面的优势。
Craniofacial disorders are among the most common human birth defects and present an enormous health care and social burden. The development of animal models has been instrumental to investigate fundamental questions in craniofacial biology and this knowledge is critical to understand the etiology and pathogenesis of these disorders. The vast majority of craniofacial disorders arise from abnormal development of the neural crest, a multipotent and migratory cell population. Therefore, defining the pathogenesis of these conditions starts with a deep understanding of the mechanisms that preside over neural crest formation and its role in craniofacial development. This review discusses several studies using Xenopus embryos to model human craniofacial conditions, and emphasizes the strength of this system to inform important biological processes as they relate to human craniofacial development and disease.