Pre-emptive analgesia and its supraspinal mechanisms: enhanced descending inhibition and decreased descending facilitation by dexmedetomidine
Pre-emptive analgesia and its supraspinal mechanisms: enhanced descending inhibition and decreased descending facilitation by dexmedetomidine
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超前镇痛及其脊髓上机制：右美托咪定增强下行抑制并降低下行促进
DOI：
10.1113/jp271991
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发表时间：
2016-04-01
影响因子：
5.5
通讯作者：
Niu, Nan
中科院分区：
文献类型：
--
作者：
You, Hao-Jun;Lei, Jing;Niu, Nan
我们研究并比较了腹腔内注射芬太尼（2- 60 gkg（-1））和右美托咪定（Dex，1- 10 gkg（-1）;一种高度选择性2-肾上腺素受体激动剂）在调节伤害性感受方面的抗伤害性作用，通过测量大鼠的伤害性缩爪反射来评估。芬太尼在1 ~ 1.5h内可使大鼠伤害性机械缩足阈升高，热缩足潜伏期延长（P
We investigated and compared the antinociceptive effects of intraperitoneal administration of fentanyl (2-60gkg(-1)) and dexmedetomidine (Dex, 1-10gkg(-1); a highly selective 2-adrenoceptor agonist) in the regulation of nociception assessed by measuring noxious paw withdrawal reflexes in rats. Fentanyl elevated noxious mechanical paw withdrawal threshold and prolonged paw withdrawal heat latency within 1-1.5h (P