Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome.
Evaluation of EEG biomarkers of Comprehensive Behavioral Intervention for Tics in children with Tourette syndrome.
复制标题
抽动秽语综合征儿童抽动综合行为干预的脑电生物标志物评价。
DOI：
10.1016/j.clinph.2022.07.500
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Sukhodolsky,DenisG
中科院分区：
文献类型：
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作者：
Morand-Beaulieu,Simon;Crowley,MichaelJ;Grantz,Heidi;Leckman,JamesF;Scahill,Lawrence;Sukhodolsky,DenisG
抽动综合行为干预（CBIT）是抽动秽语综合征（TS）的一线治疗方法。然而，CBIT涉及的大脑机制知之甚少。在Go/NoGo任务期间增强的前内侧EEG一致性被认为是参与自愿抽动控制的机制。在目前的研究中，我们进行了一项随机对照试验，以评估是否EEG的连贯性在一个去/不去的任务与CBIT outcome.MethodsThirty-two儿童TS随机分配到CBIT或治疗照常（TAU）。治疗结果由盲法评价者使用耶鲁抽动严重程度量表（YGTSS）和临床总体印象改善量表（CGI-I）进行评估。在基线和终点的Go/NoGo任务期间记录EEG。EEG的相干性计算在α频带之间的先验选择的通道对跨越额叶和motor areas.ResultsTic严重程度显着降低CBIT组。然而，CBIT没有影响EEG的连贯性和基线EEG的连贯性并没有预测treatmentoutcome.ConclusionsAlthough CBIT是上级TAU对盲的临床结局，EEG的连贯性在去/不去的任务是不相关的变化抽搐severity.SignificanceThe大脑过程中参与的运动反应的抑制似乎不参与CBIT。
ObjectiveComprehensive Behavioral Intervention for Tics (CBIT) is a first-line treatment of Tourette syndrome (TS). However, the brain mechanisms involved in CBIT are poorly understood. Enhanced frontomesial EEG coherence during a Go/NoGo task has been suggested as a mechanism involved in voluntary tic control. In the current study, we conducted a randomized controlled trial to assess whether EEG coherence during a Go/NoGo task was associated with CBIT outcome.MethodsThirty-two children with TS were randomly assigned to CBIT or to treatment-as-usual (TAU). Treatment outcome was assessed by a blinded evaluator with the Yale Global Tic Severity Scale (YGTSS) and the Clinical Global Impression – Improvement Scale (CGI-I). EEG was recorded during a Go/NoGo task at baseline and endpoint. EEG coherence was computed in the alpha frequency band between a priori selected channel pairs spanning the frontal and motor areas.ResultsTic severity decreased significantly in the CBIT group. However, CBIT did not impact EEG coherence and baseline EEG coherence did not predict treatment outcome.ConclusionsAlthough CBIT was superior to TAU on blinded clinical outcomes, EEG coherence during the Go/NoGo task was not associated with change in tic severity.SignificanceThe brain processes involved in the inhibition of motor responses do not appear to be involved in CBIT.