Post-translational modulation of pluripotency
Post-translational modulation of pluripotency
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DOI：
10.1093/jmcb/mjs031
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发表时间：
2012-08-01
影响因子：
5.5
通讯作者：
Izpisua Belmonte, Juan Carlos
中科院分区：
文献类型：
--
作者：
Cai, Ning;Li, Mo;Izpisua Belmonte, Juan Carlos
多能性的维持依赖于一个复杂的转录网络，该网络与一组关键的转录因子有关。多能干细胞已被证明对这些关键多能性因子的细胞丰度和转录活性的调节敏感。最近的证据强调了翻译后修饰的重要作用，包括泛素化、类泛素化、磷酸化、甲基化和乙酰化，在调节多能性因子的水平和活性以实现多能性和分化之间的平衡中。
The maintenance of pluripotency relies on an intricate transcriptional network hinged on a key set of transcription factors. Pluripotent stem cells have been shown to be sensitive to modulations of the cellular abundance and transcriptional activity of these key pluripotency factors. Recent evidence highlights the important role of post-translational modifications, including ubiquitination, sumoylation, phosphorylation, methylation, and acetylation, in regulating the levels and activity of pluripotency factors to achieve a balance between pluripotency and differentiation.