A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds
A "traceless" Staudinger ligation for the chemoselective synthesis of amide bonds
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DOI：
10.1021/ol006054v
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发表时间：
2000-07-13
期刊：
影响因子：
5.2
通讯作者：
Bertozzi, CR
中科院分区：
文献类型：
--
作者：
Saxon, E;Armstrong, JI;Bertozzi, CR
在这里，我们报告了我们以前报道的“施陶丁格连接”的新修改，其从叠氮化物和特定官能化的膦产生酰胺键，这种用于选择性形成酰胺键的方法，其不需要远端官能团的正交保护，应该在合成和生物化学中找到通用性。
[GRAPHICS]Here we report a novel modification of our previously reported "Staudinger ligation" that generates an amide bond from an azide and a specifically functionalized phosphine, This method for the selective formation of an amide bond, which does not require the orthogonal protection of distal functional groups, should find general utility in synthetic and biological chemistry.