Gene expression variation between African Americans and whites is associated with coronary artery calcification: the multiethnic study of atherosclerosis
Gene expression variation between African Americans and whites is associated with coronary artery calcification: the multiethnic study of atherosclerosis
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DOI：
10.1152/physiolgenomics.00243.2010
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发表时间：
2011-07-01
影响因子：
4.6
通讯作者：
Liu, Kiang
中科院分区：
文献类型：
--
作者：
Huang, Chiang-Ching;Lloyd-Jones, Donald M.;Liu, Kiang
冠状动脉钙（CAC）是动脉粥样硬化总负荷的重要指标。流行病学数据显示非裔美国人和白人在CAC患病率和严重程度上存在实质性差异。然而，对CAC发生和发展的分子机制知之甚少。在多民族动脉粥样硬化队列研究中，对119名50岁及以上的健康女性外周血白细胞进行了微阵列基因表达谱分析；48名女性的CAC评分为bb100，颈动脉内膜-中膜厚度（IMT）为> 1mm， 71名女性的CAC评分为>10，IMT
Coronary artery calcium (CAC) is a strong indicator of total atherosclerosis burden. Epidemiological data have shown substantial differences in CAC prevalence and severity between African Americans and whites. However, little is known about the molecular mechanisms underlying initiation and progression of CAC. Microarray gene expression profiling of peripheral blood leucocytes was performed from 119 healthy women aged 50 yr or above in the Multi-Ethnic Study of Atherosclerosis cohort; 48 women had CAC score >100 and carotid intima-media thickness (IMT) >1 mm, while 71 had CAC >10 and IMT