Prognostic significance of tissue carcinoembryonic antigen in mild dysplasia of the uterine cervix.
Prognostic significance of tissue carcinoembryonic antigen in mild dysplasia of the uterine cervix.
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组织癌胚抗原在宫颈轻度发育不良中的预后意义。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
T. Wahlstrom
中科院分区：
文献类型：
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作者：
J. Lindgren;E. Vesterinen;E. Purola;T. Wahlstrom
应用两种抗癌胚抗原（CEA）的鼠单克隆抗体，采用免疫过氧化物酶染色法检测宫颈轻度不典型增生中CEA的表达，以探讨其对宫颈轻度不典型增生的预后意义。高亲和力抗体（Ha）检测CEA决定簇在53%的47个病变研究，而40%的上皮变化是积极的低亲和力抗体（La）。Ha抗体染色10个进行性病变（62%），而La抗体检测CEA的决定因素在38%的这些。48%的23个消退病变的CEA阳性与Ha和39%与La抗体分别。8个持续性病变表达CEA的频率相同（50%）与两种抗体。结果表明，轻度宫颈不典型增生患者的组织CEA并不能反映恶性潜能。
Two murine monoclonal antibodies to carcinoembryonic antigen (CEA) were used to detect CEA by the immunoperoxidase staining method in mild dysplasia of the uterine cervix in order to evaluate the prognostic significance of the expression of this antigen. The high affinity antibodies (Ha) detected CEA determinants in 53% of the 47 lesions studied while 40% of the epithelial changes were positive with the low affinity antibodies (La). Ha antibodies stained ten out of the 16 progressive lesions (62%), while La antibodies detected CEA determinants in 38% of these. Forty-eight per cent of the 23 regressive lesions were CEA positive with Ha and 39% with La antibodies respectively. The eight persistent lesions expressed CEA equally frequently (50%) with both antibodies. The results indicate that tissue CEA in patients with mild cervical dysplasia does not reflect malignant potential.