Deformation of cross-linked semiflexible polymer networks
Deformation of cross-linked semiflexible polymer networks
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DOI：
10.1103/physrevlett.91.108102
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发表时间：
2003-09-05
影响因子：
8.6
通讯作者：
MacKintosh, FC
中科院分区：
文献类型：
--
作者：
Head, DA;Levine, AJ;MacKintosh, FC
丝状蛋白网络在细胞力学中发挥着至关重要的作用。这些细胞骨架网络以及各种交联和其他相关蛋白在很大程度上决定了细胞的（粘）弹性反应。在这封信中，我们研究了交联的刚性丝的模型系统，以探索应变下的微观结构与细胞骨架网络的宏观响应之间的联系。我们发现两种不同的状态主要是交联密度和细丝刚性的函数：一种以仿射变形为特征，另一种以非仿射变形为特征。我们描述了两者之间的交叉。
Networks of filamentous proteins play a crucial role in cell mechanics. These cytoskeletal networks, together with various cross-linking and other associated proteins largely determine the (visco)elastic response of cells. In this Letter we study a model system of cross-linked, stiff filaments in order to explore the connection between the microstructure under strain and the macroscopic response of cytoskeletal networks. We find two distinct regimes as a function primarily of cross-link density and filament rigidity: one characterized by affine deformation and one by nonaffine deformation. We characterize the crossover between these two.