Longitudinal Cortical Volume Changes Correlate With Motor Recovery in Patients After Acute Local Subcortical Infarction
Longitudinal Cortical Volume Changes Correlate With Motor Recovery in Patients After Acute Local Subcortical Infarction
复制标题
纵向皮质体积变化与急性局部皮质下梗塞后患者的运动恢复相关。
DOI：
10.1161/strokeaha.113.000971
复制
发表时间：
2013-10-01
期刊：
影响因子：
8.3
通讯作者：
Zeng, Jinsheng
中科院分区：
文献类型：
--
作者：
Dang, Chao;Liu, Gang;Zeng, Jinsheng
背景与目的脑梗死后急性期运动相关皮质区体积的继发性变化及其与功能恢复的关系尚未确定。在本研究中，我们量化的运动相关的皮层区域的灰质（GM）体积的变化，并分析其相关性与临床分数的患者与局灶性脑infarct.Methods 15例急性皮质下梗死进行纵向高分辨率结构MRI和临床评估3次在12周内（第1，4和12周）。14名年龄和性别匹配的对照组接受了MRI检查。采用基于体素的形态计量学方法对GM体积进行定量分析，并分析感兴趣区GM体积的变化与临床评分的关系。结果脑梗死患者在观察期内，弥漫性皮质区GM体积均明显减少，而弥漫性皮质区GM体积明显增加（P
Background and Purpose Secondary changes in the volume of motor-related cortical regions and the relationship with functional recovery during the acute stage after cerebral infarction have not been determined. In the present study, we quantified changes in gray matter (GM) volume in motor-related cortical regions and analyzed their correlations to clinical scores in patients with focal cerebral infarct.Methods Fifteen patients with acute subcortical infarct underwent longitudinal high-resolution structural MRI and clinical assessment 3 times during a 12-week period (weeks 1, 4, and 12). Fourteen age- and sex-matched controls underwent MRI examination. Voxel-based morphometry was used to quantify changes in global GM volume; in addition, relationships between GM volume changes in volumes of interest and clinical scores were analyzed.Results In patients with cerebral infarction, GM volumes detected by voxel-based morphometry both decreased and increased significantly in diffuse cortical regions during the observation period (P