Hematologic and hematopoietic consequences of B19 parvovirus infection.
Hematologic and hematopoietic consequences of B19 parvovirus infection.
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B19 细小病毒感染的血液学和造血后果。
DOI：
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发表时间：
1988
期刊：
影响因子：
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通讯作者：
N. Young
中科院分区：
文献类型：
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作者：
N. Young
在杂交实验中，B19与自主啮齿动物细小病毒显示出一定的反应性，但与腺相关病毒序列没有反应性;其末端与腺相关病毒的关系比自主细小病毒更密切。B19与所有细小病毒共享基因组左侧的保守同源区域。缺乏内部启动子和其不寻常的转录模式将B19与依赖性和自主性细小病毒分开。虽然B19显然是一种自主的细小病毒，但其非常挑剔的行为类似于一种依赖性细小病毒，只能在终末分化红系细胞的特殊核环境中复制。分子水平的适应可能是B19细小病毒获得其高度特异性和低水平致病性并因此在人群中成功所必需的。
In hybridization experiments, B19 shows some reactivity with autonomous rodent parvoviruses but none with adenoassociated virus sequences; its termini are more closely related to adenoassociated virus than to autonomous parvoviruses. B19 shares with all parvoviruses regions of conserved homology in the left side of the genome. The absence of an internal promoter and its unusual pattern of transcription sets B19 apart from both dependent and autonomous parvoviruses. Although clearly an autonomous parvovirus, in its extraordinary fastidious behavior B19 resembles a dependent parvovirus, capable of replication only in the special nuclear milieu of terminally differentiating erythroid cells. Adaptations at the molecular level may have been necessary for B19 parvovirus to acquire its high degree of specificity and low level of pathogenicity and thus succeed in human populations.