Kinetics of transfer of pyrene and rac-1-oleyl-2-[4-(3-pyrenyl)butanoyl]glycerol between human plasma lipoproteins.
Kinetics of transfer of pyrene and rac-1-oleyl-2-[4-(3-pyrenyl)butanoyl]glycerol between human plasma lipoproteins.
复制标题
芘和rac-1-油基-2-[4-(3-芘基)丁酰基]甘油在人血浆脂蛋白之间转移的动力学。
DOI：
10.1021/bi00260a018
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发表时间：
1982
期刊：
影响因子：
2.9
通讯作者：
Smith,LC
中科院分区：
文献类型：
--
作者：
Charlton,SC;Smith,LC
Steven C. Charlton1 and Louis C. Smith* abstract: Control of lipid transfer between plasma lipo-proteins has been studied with pyrene and a pyrene-containing diglyceride analogue, rae-1-oleyl-2-[4-(3-pyrenyl) butanoyl]-glycerol. The rate constants for transfer of the fluorescent probes between high-density lipoproteins in dilute solutions containing ions of the Hofmeister series are correlated with the molal surface tension increments produced by this lyotropic series. Moreover, the rates of transfercorrelate well with the aqueous solubilities of the hydrophobic compounds, which were increased indilute solutions containing organic solvents. The rates of transfer are faster with an increase in the distribution coefficients of the probes between the lipoprotein donor and the aqueousphase, suggesting that the rate-determining process can be considered simply as a partitioning between two im-miscible solvents. Rate constants for transfer of pyrene be-tween high-density, low-density, and very low density lipo-proteins depend on the ratio of the donor/acceptor lipoprotein i^ Jasma lipoproteins function as circulating reservoirs for a wide varietyof hydrophobic substances that have extremely low solubility in aqueous solutions (Smith et al., 1978; Scanu et al., 1979). These compounds include triglyceride, chole-sterol, cholesteryl ester, and phosphatidylcholine as major components and minor amounts of lipid-soluble vitamins and environmentally derived contaminants. The relatively constant compositions of the circulatingli-poproteins result from fivesimultaneous processes:(1) synthesis and secretion,(2) passive transfer and exchange of lipid
