Antidepressant-withdrawal mania:a critical review and synthesis of the literature.
Antidepressant-withdrawal mania:a critical review and synthesis of the literature.
复制标题
抗抑郁药戒断躁狂：文献的批判性回顾和综合。
DOI：
--
复制
发表时间：
2004
影响因子：
5.3
通讯作者：
C. Andrade
中科院分区：
文献类型：
--
作者：
C. Andrade
背景
在停用抗抑郁药物后不久，很少有轻躁狂或躁狂的报告。这种停药综合征的真实发生率尚不清楚，因为可能由于认识不足或错误归因而少报。本文探讨了可能的病因学，疾病分类学，机制，和其他方面的综合征。
数据来源和研究选择
在2003年5月进行了PubMed检索，并在2004年1月使用检索词抗抑郁药和躁狂症进行了重复检索。检索了包含充分描述的相关文章，并手动检索其参考文献列表以获得更多相关材料。1998年至2003年，还对主要精神病学期刊的索引进行了手工检索。确定了23篇文章进行审查。
结论
几乎所有抗抑郁药在突然停药、逐渐减量停药或仅减少剂量后，都很少发生抗抑郁药停药轻躁狂或躁狂。该综合征可能是自限性的，可能随着抗抑郁药物的重新使用而减轻，或者可能需要特定的抗躁狂治疗;情绪稳定剂不一定能预防该综合征。该综合征的真实发病率尚不清楚。狭义和广义的诊断标准提出了综合征，并提供了一个综合文献。
BACKGROUND
Hypomania or mania have rarely been reported to develop shortly after the discontinuation of an antidepressant drug. The true incidence of this discontinuation syndrome is unknown because it may be underreported as a consequence of underrecognition or misattribution. This article examines the possible etiology, nosology, mechanisms, and other aspects of the syndrome.
DATA SOURCES AND STUDY SELECTION
A PubMed search was conducted in May 2003 and repeated in January 2004 using the search terms antidepressant and mania. Relevant articles containing adequate descriptions for presentation were retrieved, and their reference lists were hand-searched for further pertinent material. Hand-searches of the indexes of leading psychiatry journals were also performed for the years 1998-2003. Twenty-three articles were identified for review.
CONCLUSIONS
Antidepressant-withdrawal hypomania or mania may occur rarely with almost any antidepressant drug after sudden withdrawal, tapered discontinuation, or even merely a decrease in dose. The syndrome may be self-limiting, may abate with the reinstitution of the antidepressant drug, or may require specific anti-manic treatments; mood stabilizers do not necessarily protect against the syndrome. The true incidence of the syndrome is unknown. Narrow and broad diagnostic criteria are proposed for the syndrome, and a synthesis of literature is provided.