Immune modulators in the context of the ovulatory process: a role for interleukin-1.
Immune modulators in the context of the ovulatory process: a role for interleukin-1.
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排卵过程中的免疫调节剂：IL-1 的作用。
DOI：
10.1111/j.1600-0897.1996.tb00030.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Adashi,EY
中科院分区：
文献类型：
--
作者：
Adashi,EY
最近的研究已经确定了卵巢内存在一个完整的白细胞介素-1系统，充满了配体，受体和受体拮抗剂。本文探讨了卵巢内IL-1可能在排卵过程中发挥中介作用的假设。更具体地说，假设卵巢内IL-1β可能在诱导排卵中构成促性腺激素的介质，是一种能够协调和放大排卵级联反应关键组分的效应物。从这项研究中获得的见解可能会导致阐明排卵过程中的一些分子事件，描述全身性抗IL-1治疗的生殖副作用，并可能改善促进生育或控制生育的策略。
Recent studies have established the existence of a complete intraovarian interleukin‐1 system replete with ligends, receptors, and a receptor antagonist. This article examines the hypothesis that intraovarian IL‐1 may play an intermediary role in the ovulatory process. More specifically, it is hypothesized that intraovarian IL‐1β may constitute a mediator of gonadotropins in the induction of ovulation, an effector capable of coordinating and amplifying key components of the ovulatory cascade. The insight derived from this investigation may result the elucidation of some of the molecular events underlying the ovulatory process, in the delineation of the reproductive side effects of systemic anti‐IL‐1 therapy, and in potentially improved strategies for the promotion of fertility or its control.