Framingham stroke risk profile and lowered cognitive performance
Framingham stroke risk profile and lowered cognitive performance
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DOI：
10.1161/01.str.0000103141.82869.77
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发表时间：
2004-02-01
期刊：
影响因子：
8.3
通讯作者：
Wolf, PA
中科院分区：
文献类型：
--
作者：
Elias, MF;Sullivan, LM;Wolf, PA
背景和目的--这项工作的主要目标是描述在风险评估时没有中风和痴呆症临床症状的大量社区样本中中风的10年风险与认知表现的多项测量之间的关系。方法-来自Framingham子孙研究的1011名男性和1164名女性的参与者。弗雷明翰卒中风险概况用于评估卒中的10年风险。采用横断面设计，我们在弗雷明翰后代研究的第7次检查中，评估了中风的10年风险，即预测变量，以及认知表现，即结果变量。结果：在对年龄、教育程度、性别和其他与中风和认知能力相关的因素进行统计调整后，在视觉空间记忆、注意力、组织、扫描和抽象推理的测试中，观察到10年中风风险的增量与认知表现水平呈负相关。结论：在没有中风和痴呆症的个体中，中风的10年风险较高与多个认知领域的表现减退有关。
Background and Purpose - The primary objective of this work was to describe the relationships between 10-year risk for stroke and multiple measures of cognitive performance for a large community-based sample of individuals who were free of clinical stroke and dementia at the time of risk assessment.Methods - Participants were 1011 men and 1164 women from the Framingham Offspring Study. The Framingham Stroke Risk Profile was used to assess 10-year risk of stroke. Using a cross-sectional design, we assessed 10-year risk of stroke, the predictor variable, and cognitive performance, the outcome variable, at examination 7 of the Framingham Offspring Study. Multivariable linear regression models were used to relate 10-year risk of stroke to cognitive tests measuring multiple domains of cognitive functioning.Results - With statistical adjustment for age, education, sex, and other correlates of both stroke and cognitive ability, an inverse association between increments in 10-year risk of stroke and cognitive performance level was observed for tests indexing visual-spatial memory, attention, organization, scanning, and abstract reasoning.Conclusions - In stroke-and dementia-free individuals, higher 10-year risk for stroke is associated with performance decrements in multiple cognitive domains.