Anti-inflammatory phytochemicals for chemoprevention of colon cancer.
Anti-inflammatory phytochemicals for chemoprevention of colon cancer.
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DOI：
10.2174/15680096113139990036
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发表时间：
2013-05
影响因子：
3
通讯作者：
Venkateshwar Madka;C. Rao
中科院分区：
文献类型：
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作者：
Venkateshwar Madka;C. Rao
据报道，全球每年有100多万新的癌症病例和60万人死亡。结直肠癌是美国第四大最常见的癌症死亡原因，也是第二大癌症死亡原因。通过流行病学、实验室和临床研究，对结直肠癌的认识已经取得了重大进展。转移性腺癌的发展是一个多阶段的过程，在此过程中会发生多种基因改变和病理生理变化。如果能够阻止或逆转正常结肠隐窝细胞向恶性的转化，结直肠癌是可以预防的。一些在结直肠肿瘤进展中起重要作用并显著改变的关键分子与炎症有关。由于慢性炎症现在被认为是肿瘤发展的潜在危险因素，在临床前和临床研究中，靶向炎症通路已被证明在预防结肠肿瘤的形成及其恶性进展方面是有效的。合成非类固醇抗炎药(NSAIDs)已被确定为潜在的结直肠癌化学预防药物；然而，这些合成药物大多与有害的副作用有关，有时甚至是致命的。越来越多的证据支持具有抗炎活性的天然植物化学物质的功效。在这篇综述中，我们讨论了与结直肠癌相关的关键炎症途径，并展望了自然产生的植物化学物质作为抗炎药物预防和治疗结直肠癌的前景。
Every year more than a million new cancer cases and 600,000 deaths are reported world-wide. Colorectal cancer is the fourth most commonly occurring and second leading cause of cancer deaths in the United States. Significant progress has been made in understanding colorectal cancer through epidemiological, laboratory and clinical studies. Development of metastatic adenocarcinomas is a multistage process occurring over several years during which multiple genetic alterations and pathophysiological changes are associated. Colorectal cancer can be prevented if the transformation of normal colonic crypt cells to malignant can be halted or reversed. Some of the key molecules that are altered significantly and play important roles in colorectal tumor progression are associated with inflammation. Since chronic inflammation is now recognized as a potential risk factor for tumor development, targeting inflammatory pathways has proven effective in preventing formation of colonic tumors and their malignant progression in both preclinical and clinical studies. Synthetic non-steroidal anti-inflammatory drugs (NSAIDS) have been identified as potential colorectal cancer chemopreventive agents; however, most of these synthetic agents are associated with unwanted and sometimes fatal side effects. There is mounting evidence in support of the efficacy of naturally-occurring phytochemicals possessing anti-inflammatory activity. In this review we discuss key inflammatory pathways associated with colorectal cancer and promising naturally-occurring phytochemicals as anti-inflammatory agents for the prevention and treatment of colorectal cancer.