Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects
Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects
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DOI：
10.1164/ajrccm.155.6.9196088
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发表时间：
1997-06-01
影响因子：
24.7
通讯作者：
Busse, WW
中科院分区：
文献类型：
--
作者：
Gern, JE;Calhoun, W;Busse, WW
鼻病毒(RV)感染是易感人群急性哮喘症状的重要触发因素。为了确定过敏的存在是否是轮状病毒感染期间下呼吸道效应增强的风险因素，我们通过实验感染(RV16)18名患有变应性鼻炎的志愿者和13名正常对照受试者，并测量了它们对下呼吸道对组胺反应的影响。所有受试者都被成功感染，这表明上呼吸道症状增加，鼻腔分泌物培养出RV16。RV感染引起的组胺PD20(Delta PD20)的变化在过敏组和非过敏组有显著差异(Delta PD20=-0.40比-0.03个对数单位，p=0.04)。在调整了初始PD20和FEV1后，这种关系得到了加强(平均增量PD20=-0.43，而不是0.01个对数单位，p<；0.01)。病毒诱导的Delta PD20也受基线肺功能的影响：初始FEV1与Delta PD20呈正相关，基线PD20与Delta PD20呈微弱但显著的负相关。这些发现表明，宿主因素，如变态反应、基线FEV1和基线PD20影响RV感染引起的下呼吸道生理变化，并增加了这些因素导致哮喘患者RV感染下呼吸道效应增加的可能性。
Rhinovirus (RV) infections are important triggers of acute asthma symptoms in susceptible persons. To determine whether the presence of allergy is a risk factor for enhanced lower airway effects during RV infection, we experimentally infected (RV16) 18 volunteers with allergic rhinitis and 13 normal control subjects and measured the effects on the response of the lower airways to histamine. All subjects were successfully infected, as indicated by increased upper respiratory symptoms and RV16 cultured from nasal secretions. The change in histamine PD20(Delta PD20) caused by RV infection was significantly different in allergic subjects from that in nonallergic control subjects (Delta PD20 = -0.40 versus -0.03 log units, p = 0.04). This relationship was strengthened after adjusting for initial PD20 and FEV1 (mean Delta PD20 = -0.43 versus 0.01 log units, p < 0.01). The virus-induced Delta PD20 was also influenced by baseline lung function: there was a positive correlation between initial FEV1 and Delta PD20, and a weak but significant negative correlation between baseline PD20 and Delta PD20. These findings indicate that host factors such as allergy, baseline FEV1, and baseline PD20 influence the changes in lower airway physiology caused by RV infection and raise the possibility that these factors contribute to the increased lower airway effects of RV infection in subjects with asthma.