Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors.
Impact of Weight Loss on Plasma Leptin and Adiponectin in Overweight-to-Obese Post Menopausal Breast Cancer Survivors.
复制标题
DOI：
10.3390/nu7075156
复制
发表时间：
2015-06-26
期刊：
影响因子：
5.9
通讯作者：
Matthews SB
中科院分区：
文献类型：
--
作者：
Thompson HJ;Sedlacek SM;Wolfe P;Paul D;Lakoski SG;Playdon MC;McGinley JN;Matthews SB
在乳腺癌诊断时肥胖的妇女比正常体重的妇女有更高的总死亡率，一些证据表明脂联素和瘦素是预后不利因素。虽然有意减肥被认为可以改善预后，但其对这些脂肪因子的影响尚不清楚。这项研究比较了超重至肥胖的绝经后乳腺癌幸存者在减肥过程中血浆瘦素和脂联素的变化模式。考虑到关于什么样的饮食模式最适合乳腺癌控制和脂肪因子代谢调节的争议，使用非随机对照研究设计评估了低脂与低碳水化合物模式的效果。在为期六个月的减肥干预期间，每月获得人体测量数据和空腹血浆。瘦素与脂肪量相关，脂联素与脂肪量无关，在整个减肥过程中瘦素和脂联素浓度之间缺乏相关性意味着独立的调节机制。瘦素而非脂联素变化的时间模式受体重减轻幅度的影响。饮食模式对两种脂肪因子均无影响。与饮食模式、体重减轻或脂肪量没有直接关系的机制似乎在这些脂肪因子的循环水平的调节中起主导作用。
Women who are obese at the time of breast cancer diagnosis have higher overall mortality than normal weight women and some evidence implicates adiponectin and leptin as contributing to prognostic disadvantage. While intentional weight loss is thought to improve prognosis, its impact on these adipokines is unclear. This study compared the pattern of change in plasma leptin and adiponectin in overweight-to-obese post-menopausal breast cancer survivors during weight loss. Given the controversies about what dietary pattern is most appropriate for breast cancer control and regulation of adipokine metabolism, the effect of a low fat versus a low carbohydrate pattern was evaluated using a non-randomized, controlled study design. Anthropometric data and fasted plasma were obtained monthly during the six-month weight loss intervention. While leptin was associated with fat mass, adiponectin was not, and the lack of correlation between leptin and adiponectin concentrations throughout weight loss implies independent mechanisms of regulation. The temporal pattern of change in leptin but not adiponectin was affected by magnitude of weight loss. Dietary pattern was without effect on either adipokine. Mechanisms not directly related to dietary pattern, weight loss, or fat mass appear to play dominant roles in the regulation of circulating levels of these adipokines.